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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE9A
All Species:
17.58
Human Site:
Y375
Identified Species:
32.22
UniProt:
O76083
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76083
NP_001001567.1
593
68493
Y375
R
T
E
L
A
V
R
Y
N
D
I
S
P
L
E
Chimpanzee
Pan troglodytes
XP_001140174
593
68430
Y375
R
T
E
L
A
V
R
Y
N
D
I
S
P
L
E
Rhesus Macaque
Macaca mulatta
NP_001154921
533
61639
T334
A
V
A
F
Q
I
L
T
E
P
E
C
N
I
F
Dog
Lupus familis
XP_853727
850
94841
M365
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
Cat
Felis silvestris
Mouse
Mus musculus
O70628
534
61617
E336
F
Q
I
L
A
R
P
E
C
N
I
F
A
S
V
Rat
Rattus norvegicus
P14270
803
90534
Y520
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511668
533
61943
A334
A
V
A
F
Q
I
I
A
Q
P
E
C
N
I
F
Chicken
Gallus gallus
XP_416748
516
59987
D317
E
L
A
V
R
Y
N
D
I
S
P
L
E
N
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001340244
516
59766
S317
A
V
R
Y
N
D
I
S
P
L
E
N
H
H
C
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
Y681
G
S
A
L
S
L
L
Y
G
T
S
A
T
L
E
Fruit Fly
Dros. melanogaster
P12252
1070
115060
Y795
S
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
Y470
N
N
E
L
A
I
M
Y
N
D
E
S
V
L
E
Sea Urchin
Strong. purpuratus
XP_794310
409
47790
P210
I
R
Y
N
D
I
S
P
L
E
N
H
H
C
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
88.8
58.5
N.A.
83.1
24
N.A.
73.8
76.7
N.A.
67.6
21.1
20.1
N.A.
25.8
44.8
Protein Similarity:
100
99.4
89.3
61.4
N.A.
87.1
41.2
N.A.
80.2
82.4
N.A.
79.7
36.5
34.6
N.A.
44
56.8
P-Site Identity:
100
100
0
13.3
N.A.
20
60
N.A.
0
0
N.A.
0
26.6
60
N.A.
60
0
P-Site Similarity:
100
100
13.3
26.6
N.A.
26.6
73.3
N.A.
13.3
6.6
N.A.
6.6
53.3
73.3
N.A.
66.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
31
0
54
0
0
8
8
0
0
16
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
16
0
8
8
% C
% Asp:
0
0
0
0
8
8
8
8
0
39
0
0
0
0
0
% D
% Glu:
8
0
39
0
0
0
0
8
8
8
39
0
16
0
47
% E
% Phe:
8
0
0
16
0
0
0
0
0
0
0
8
0
0
16
% F
% Gly:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
8
16
8
8
% H
% Ile:
8
0
16
0
0
31
16
0
8
0
24
0
0
24
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
16
0
62
0
24
16
0
8
8
0
8
0
47
0
% L
% Met:
0
0
0
0
0
0
24
8
0
0
0
0
0
0
8
% M
% Asn:
16
8
0
8
8
0
8
0
39
8
8
8
16
8
0
% N
% Pro:
0
0
0
0
0
0
8
8
8
16
8
0
16
0
0
% P
% Gln:
0
8
0
0
16
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
16
8
8
0
8
8
16
0
0
8
0
0
0
0
0
% R
% Ser:
8
24
0
0
8
0
8
8
0
8
16
39
0
8
0
% S
% Thr:
8
16
0
0
0
8
0
8
0
8
0
0
8
0
0
% T
% Val:
0
24
0
8
0
16
0
0
0
0
0
0
24
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
0
8
0
47
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _