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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE9A
All Species:
4.55
Human Site:
Y444
Identified Species:
8.33
UniProt:
O76083
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76083
NP_001001567.1
593
68493
Y444
E
K
M
E
N
F
D
Y
S
N
E
E
H
M
T
Chimpanzee
Pan troglodytes
XP_001140174
593
68430
Y444
E
K
M
E
N
F
D
Y
S
N
E
E
H
M
T
Rhesus Macaque
Macaca mulatta
NP_001154921
533
61639
K394
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
Dog
Lupus familis
XP_853727
850
94841
K449
M
D
R
D
K
V
T
K
A
T
A
Q
I
G
F
Cat
Felis silvestris
Mouse
Mus musculus
O70628
534
61617
L396
L
T
L
L
K
M
I
L
I
K
C
C
D
I
S
Rat
Rattus norvegicus
P14270
803
90534
V589
T
M
V
E
T
K
K
V
T
S
S
G
V
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511668
533
61943
K394
T
F
S
L
F
Q
L
K
M
V
L
I
K
C
C
Chicken
Gallus gallus
XP_416748
516
59987
E377
E
I
L
D
S
F
K
E
K
M
E
N
F
D
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001340244
516
59766
D378
D
S
F
K
Q
K
V
D
S
F
D
Y
N
N
E
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
W752
V
S
I
G
E
Y
N
W
N
V
K
T
H
R
D
Fruit Fly
Dros. melanogaster
P12252
1070
115060
V864
T
M
V
E
T
K
K
V
A
G
S
G
V
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22000
674
75370
E535
A
D
L
K
T
M
V
E
A
K
K
V
A
G
N
Sea Urchin
Strong. purpuratus
XP_794310
409
47790
E270
D
Q
F
K
A
Q
V
E
S
G
F
D
F
S
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
88.8
58.5
N.A.
83.1
24
N.A.
73.8
76.7
N.A.
67.6
21.1
20.1
N.A.
25.8
44.8
Protein Similarity:
100
99.4
89.3
61.4
N.A.
87.1
41.2
N.A.
80.2
82.4
N.A.
79.7
36.5
34.6
N.A.
44
56.8
P-Site Identity:
100
100
6.6
0
N.A.
0
6.6
N.A.
0
20
N.A.
6.6
6.6
6.6
N.A.
0
6.6
P-Site Similarity:
100
100
13.3
20
N.A.
20
33.3
N.A.
0
40
N.A.
33.3
46.6
26.6
N.A.
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
24
0
8
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
8
0
16
16
% C
% Asp:
16
16
0
16
0
0
16
8
0
0
8
8
8
8
8
% D
% Glu:
31
8
0
31
8
0
0
24
0
0
24
16
0
0
8
% E
% Phe:
0
8
16
0
8
24
0
0
0
8
8
0
16
0
8
% F
% Gly:
0
0
0
8
0
0
0
0
0
16
0
16
0
16
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
24
0
0
% H
% Ile:
0
8
8
0
0
0
8
0
8
8
0
16
8
8
0
% I
% Lys:
0
16
0
24
16
24
24
24
8
16
16
0
16
0
0
% K
% Leu:
8
0
24
16
0
8
16
8
0
0
16
0
0
16
16
% L
% Met:
8
16
16
8
0
16
0
0
16
8
0
0
0
16
0
% M
% Asn:
0
0
0
0
16
0
8
0
8
16
0
8
8
8
16
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
8
16
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
16
8
0
8
0
0
0
31
8
16
0
0
8
8
% S
% Thr:
24
8
0
0
31
0
8
0
8
8
0
8
0
0
16
% T
% Val:
8
0
16
0
0
8
24
16
0
16
0
8
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
16
0
0
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _