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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DOM3Z All Species: 13.94
Human Site: S203 Identified Species: 27.88
UniProt: O77932 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O77932 NP_005501.2 396 44929 S203 C A D K P G S S P D P S G E V
Chimpanzee Pan troglodytes XP_001161885 396 44867 S203 C A D K P G S S P D P S G E V
Rhesus Macaque Macaca mulatta XP_001106541 251 28178 E64 S S P D P S G E V N T N V A F
Dog Lupus familis XP_538842 347 39553 V160 S P D P S G D V N T N V A F C
Cat Felis silvestris
Mouse Mus musculus O70348 397 45262 S203 C A D K P G G S P D P S G E V
Rat Rattus norvegicus Q6MG77 397 45281 S203 C A D K P G G S P D P S G E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512198 126 14180
Chicken Gallus gallus
Frog Xenopus laevis Q5HZT0 401 46175 S211 Y S G Y K F E S Y I C A D S P
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10660 393 45840 Q190 A K N R D L N Q T D L D K R M
Sea Urchin Strong. purpuratus XP_783738 649 73632 Q217 T S D D E R S Q P D T T K P V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RY73 544 60363 P333 Y L D V H K L P E R P Q S D L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q9HE87 383 44364 E185 Q T S R D F I E S R P D H V V
Conservation
Percent
Protein Identity: 100 99.2 60.6 77.5 N.A. 90.1 90.4 N.A. 23.4 N.A. 52.6 N.A. N.A. N.A. N.A. 25.5 28.8
Protein Similarity: 100 99.4 62.3 81.3 N.A. 93.9 94.2 N.A. 29 N.A. 65.5 N.A. N.A. N.A. N.A. 45.9 41.6
P-Site Identity: 100 100 6.6 13.3 N.A. 93.3 93.3 N.A. 0 N.A. 6.6 N.A. N.A. N.A. N.A. 6.6 33.3
P-Site Similarity: 100 100 26.6 13.3 N.A. 93.3 93.3 N.A. 0 N.A. 20 N.A. N.A. N.A. N.A. 33.3 46.6
Percent
Protein Identity: N.A. N.A. N.A. 22 N.A. 29.2
Protein Similarity: N.A. N.A. N.A. 36.7 N.A. 43.4
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 34 0 0 0 0 0 0 0 0 0 9 9 9 0 % A
% Cys: 34 0 0 0 0 0 0 0 0 0 9 0 0 0 9 % C
% Asp: 0 0 59 17 17 0 9 0 0 50 0 17 9 9 0 % D
% Glu: 0 0 0 0 9 0 9 17 9 0 0 0 0 34 0 % E
% Phe: 0 0 0 0 0 17 0 0 0 0 0 0 0 9 9 % F
% Gly: 0 0 9 0 0 42 25 0 0 0 0 0 34 0 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 9 0 0 % H
% Ile: 0 0 0 0 0 0 9 0 0 9 0 0 0 0 0 % I
% Lys: 0 9 0 34 9 9 0 0 0 0 0 0 17 0 0 % K
% Leu: 0 9 0 0 0 9 9 0 0 0 9 0 0 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 9 0 0 0 9 0 9 9 9 9 0 0 0 % N
% Pro: 0 9 9 9 42 0 0 9 42 0 50 0 0 9 9 % P
% Gln: 9 0 0 0 0 0 0 17 0 0 0 9 0 0 0 % Q
% Arg: 0 0 0 17 0 9 0 0 0 17 0 0 0 9 0 % R
% Ser: 17 25 9 0 9 9 25 42 9 0 0 34 9 9 0 % S
% Thr: 9 9 0 0 0 0 0 0 9 9 17 9 0 0 0 % T
% Val: 0 0 0 9 0 0 0 9 9 0 0 9 9 9 50 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 17 0 0 9 0 0 0 0 9 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _