KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACTL6B
All Species:
29.7
Human Site:
S110
Identified Species:
50.26
UniProt:
O94805
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O94805
NP_057272.1
426
46877
S110
T
Y
S
K
H
V
K
S
E
P
N
L
H
P
V
Chimpanzee
Pan troglodytes
XP_001140943
374
41374
R78
P
W
N
T
R
A
K
R
E
K
L
T
E
L
M
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_850533
409
44735
S110
T
Y
S
K
H
V
K
S
E
P
N
L
H
P
V
Cat
Felis silvestris
Mouse
Mus musculus
Q99MR0
426
46873
S110
T
Y
S
K
H
V
K
S
E
P
N
L
H
P
V
Rat
Rattus norvegicus
NP_001034122
429
47402
S113
T
Y
K
M
H
V
K
S
E
A
S
L
H
P
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521333
303
33827
Chicken
Gallus gallus
XP_422784
720
79965
S113
T
Y
K
M
H
I
K
S
E
A
S
L
H
P
V
Frog
Xenopus laevis
NP_001080451
429
47605
S113
T
Y
K
T
H
I
K
S
E
T
N
L
H
P
V
Zebra Danio
Brachydanio rerio
NP_775347
429
47223
S113
T
Y
K
M
H
F
K
S
Q
P
G
L
H
P
V
Tiger Blowfish
Takifugu rubipres
P53480
377
41956
W81
E
H
G
I
I
T
N
W
D
D
M
E
K
I
W
Fruit Fly
Dros. melanogaster
NP_611209
425
47301
S118
A
Y
A
N
V
I
Q
S
E
P
E
Y
H
P
V
Honey Bee
Apis mellifera
XP_625202
440
49061
S121
T
Y
S
K
V
I
Q
S
D
A
E
Y
H
P
V
Nematode Worm
Caenorhab. elegans
P10986
376
41759
N79
I
E
H
G
I
V
T
N
W
D
D
M
E
K
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84M92
441
48918
I120
A
F
K
S
C
L
M
I
D
P
T
E
H
P
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.7
N.A.
93.9
N.A.
99.7
84.1
N.A.
64
52.2
83.6
83.6
36.3
57.2
60.6
36.8
N.A.
Protein Similarity:
100
87.7
N.A.
95
N.A.
100
92.5
N.A.
68.3
56.2
91.8
92.3
54.2
75.1
77.2
54.2
N.A.
P-Site Identity:
100
13.3
N.A.
100
N.A.
100
73.3
N.A.
0
66.6
73.3
66.6
0
46.6
53.3
6.6
N.A.
P-Site Similarity:
100
33.3
N.A.
100
N.A.
100
80
N.A.
0
80
80
73.3
13.3
66.6
73.3
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.9
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
8
0
0
8
0
0
0
22
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
22
15
8
0
0
0
0
% D
% Glu:
8
8
0
0
0
0
0
0
58
0
15
15
15
0
0
% E
% Phe:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
8
0
0
0
0
0
0
8
0
0
0
0
% G
% His:
0
8
8
0
50
0
0
0
0
0
0
0
72
0
0
% H
% Ile:
8
0
0
8
15
29
0
8
0
0
0
0
0
8
8
% I
% Lys:
0
0
36
29
0
0
58
0
0
8
0
0
8
8
0
% K
% Leu:
0
0
0
0
0
8
0
0
0
0
8
50
0
8
0
% L
% Met:
0
0
0
22
0
0
8
0
0
0
8
8
0
0
15
% M
% Asn:
0
0
8
8
0
0
8
8
0
0
29
0
0
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
43
0
0
0
72
0
% P
% Gln:
0
0
0
0
0
0
15
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
0
29
8
0
0
0
65
0
0
15
0
0
0
0
% S
% Thr:
58
0
0
15
0
8
8
0
0
8
8
8
0
0
0
% T
% Val:
0
0
0
0
15
36
0
0
0
0
0
0
0
0
65
% V
% Trp:
0
8
0
0
0
0
0
8
8
0
0
0
0
0
8
% W
% Tyr:
0
65
0
0
0
0
0
0
0
0
0
15
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _