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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRPF6 All Species: 32.12
Human Site: S185 Identified Species: 58.89
UniProt: O94906 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O94906 NP_036601.2 941 106925 S185 K L T P V P D S F F A K H L Q
Chimpanzee Pan troglodytes XP_001152053 941 106833 S185 K L T P V P D S F F A K H L Q
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_534481 1000 112841 S244 K L T P V P D S F F A K H L Q
Cat Felis silvestris
Mouse Mus musculus Q91YR7 941 106703 S185 K L T P V P D S F F A K H L Q
Rat Rattus norvegicus NP_001073234 941 106745 S185 K L T P V P D S F F A K H L Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507659 1026 115336 S270 K L T P V P D S F F A K H L Q
Chicken Gallus gallus XP_417426 941 106786 S185 K L T P V P D S F F A K H L Q
Frog Xenopus laevis NP_001087374 948 107315 S192 K L T P V P D S F F A K H L Q
Zebra Danio Brachydanio rerio NP_997820 944 106866 T188 N P R Y E K L T P V P D S F F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649073 931 105209 Q175 G D S R N R K Q R N P R A E K
Honey Bee Apis mellifera XP_623891 931 105090 Q174 G D A R N R K Q R N P R A E K
Nematode Worm Caenorhab. elegans NP_507525 968 109143 H211 M N Y G Q M S H S I D S G N G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P19735 899 104211 D175 K L L Q S Q I D E N L A Q L T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 91.9 N.A. 98.3 98.1 N.A. 89.3 97.2 94.4 91.8 N.A. 71.7 73.5 55.1 N.A.
Protein Similarity: 100 99.6 N.A. 93.5 N.A. 99.2 99.2 N.A. 90.7 98.8 97.1 95.5 N.A. 84.8 86 71.6 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 100 0 N.A. 0 0 0 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 100 6.6 N.A. 20 13.3 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 48.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 0 0 0 62 8 16 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 16 0 0 0 0 62 8 0 0 8 8 0 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 8 0 0 0 0 16 0 % E
% Phe: 0 0 0 0 0 0 0 0 62 62 0 0 0 8 8 % F
% Gly: 16 0 0 8 0 0 0 0 0 0 0 0 8 0 8 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 62 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % I
% Lys: 70 0 0 0 0 8 16 0 0 0 0 62 0 0 16 % K
% Leu: 0 70 8 0 0 0 8 0 0 0 8 0 0 70 0 % L
% Met: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 0 16 0 0 0 0 24 0 0 0 8 0 % N
% Pro: 0 8 0 62 0 62 0 0 8 0 24 0 0 0 0 % P
% Gln: 0 0 0 8 8 8 0 16 0 0 0 0 8 0 62 % Q
% Arg: 0 0 8 16 0 16 0 0 16 0 0 16 0 0 0 % R
% Ser: 0 0 8 0 8 0 8 62 8 0 0 8 8 0 0 % S
% Thr: 0 0 62 0 0 0 0 8 0 0 0 0 0 0 8 % T
% Val: 0 0 0 0 62 0 0 0 0 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _