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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA8 All Species: 23.03
Human Site: S1292 Identified Species: 50.67
UniProt: O94911 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O94911 NP_009099.1 1581 179245 S1292 N G A G K S T S I K V I T G D
Chimpanzee Pan troglodytes XP_001165971 1581 179231 S1292 N G A G K S T S I K V I T G D
Rhesus Macaque Macaca mulatta XP_001082492 1581 179168 S1292 N G A G K S T S I K V I T G D
Dog Lupus familis XP_548020 1622 184532 S1333 N G A G K S T S I Q V I T G D
Cat Felis silvestris
Mouse Mus musculus Q8K440 1620 183021 S1330 N G A G K S T S L K M I S G D
Rat Rattus norvegicus Q8CF82 1642 185792 V1347 S T I I N I L V G D V E P T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509469 1722 195635 I1427 S T L I N M L I G D V E P T S
Chicken Gallus gallus XP_415691 1546 175373 G1257 T V I K M I A G E T A L T A G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001092716 1654 185619 S1347 S T I M H M L S G D T E A T A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 N1395 F G R F T A V N E L C L A V D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 T1500 N G A G K T T T L S M L S G E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 96.7 77.1 N.A. 73.5 40.3 N.A. 39.4 46.1 N.A. 42.4 N.A. N.A. N.A. 22 N.A.
Protein Similarity: 100 99.5 97.9 85.4 N.A. 83.5 60.1 N.A. 59 63.5 N.A. 60.8 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 80 6.6 N.A. 6.6 6.6 N.A. 6.6 N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 13.3 13.3 N.A. 13.3 N.A. N.A. N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 93.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 55 0 0 10 10 0 0 0 10 0 19 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 28 0 0 0 0 55 % D
% Glu: 0 0 0 0 0 0 0 0 19 0 0 28 0 0 10 % E
% Phe: 10 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 64 0 55 0 0 0 10 28 0 0 0 0 55 10 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 28 19 0 19 0 10 37 0 0 46 0 0 0 % I
% Lys: 0 0 0 10 55 0 0 0 0 37 0 0 0 0 0 % K
% Leu: 0 0 10 0 0 0 28 0 19 10 0 28 0 0 0 % L
% Met: 0 0 0 10 10 19 0 0 0 0 19 0 0 0 0 % M
% Asn: 55 0 0 0 19 0 0 10 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 19 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % Q
% Arg: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 28 0 0 0 0 46 0 55 0 10 0 0 19 0 19 % S
% Thr: 10 28 0 0 10 10 55 10 0 10 10 0 46 28 0 % T
% Val: 0 10 0 0 0 0 10 10 0 0 55 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _