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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA8 All Species: 39.39
Human Site: T524 Identified Species: 86.67
UniProt: O94911 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O94911 NP_009099.1 1581 179245 T524 H S G A G K S T L L N I L S G
Chimpanzee Pan troglodytes XP_001165971 1581 179231 T524 H S G A G K S T L L N I L S G
Rhesus Macaque Macaca mulatta XP_001082492 1581 179168 T524 H S G A G K S T L L N I L S G
Dog Lupus familis XP_548020 1622 184532 T524 H S G A G K S T L L N I L S G
Cat Felis silvestris
Mouse Mus musculus Q8K440 1620 183021 T523 H S G A G K S T L L N I L S G
Rat Rattus norvegicus Q8CF82 1642 185792 T522 H S G T G K S T L M N I L C G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509469 1722 195635 T602 H S G T G K S T L M N I L C G
Chicken Gallus gallus XP_415691 1546 175373 T510 G V C P Q F N T Q F E V L T V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001092716 1654 185619 T525 H S G A G K S T L M N I L C G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 T588 H N G A G K S T T F S S I A G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 T593 H N G A G K S T T I S M L V G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 96.7 77.1 N.A. 73.5 40.3 N.A. 39.4 46.1 N.A. 42.4 N.A. N.A. N.A. 22 N.A.
Protein Similarity: 100 99.5 97.9 85.4 N.A. 83.5 60.1 N.A. 59 63.5 N.A. 60.8 N.A. N.A. N.A. 41.2 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 80 N.A. 80 13.3 N.A. 86.6 N.A. N.A. N.A. 53.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 86.6 N.A. 86.6 33.3 N.A. 93.3 N.A. N.A. N.A. 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 24.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 60 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 86.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 73 0 0 0 0 0 0 0 0 0 10 0 % A
% Cys: 0 0 10 0 0 0 0 0 0 0 0 0 0 28 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % E
% Phe: 0 0 0 0 0 10 0 0 0 19 0 0 0 0 0 % F
% Gly: 10 0 91 0 91 0 0 0 0 0 0 0 0 0 91 % G
% His: 91 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 10 0 73 10 0 0 % I
% Lys: 0 0 0 0 0 91 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 73 46 0 0 91 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 28 0 10 0 0 0 % M
% Asn: 0 19 0 0 0 0 10 0 0 0 73 0 0 0 0 % N
% Pro: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 10 0 0 0 10 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 73 0 0 0 0 91 0 0 0 19 10 0 46 0 % S
% Thr: 0 0 0 19 0 0 0 100 19 0 0 0 0 10 0 % T
% Val: 0 10 0 0 0 0 0 0 0 0 0 10 0 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _