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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HEXIM1
All Species:
15.45
Human Site:
S158
Identified Species:
37.78
UniProt:
O94992
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O94992
NP_006451.1
359
40623
S158
K
K
H
R
R
R
P
S
K
K
K
R
H
W
K
Chimpanzee
Pan troglodytes
XP_001141303
308
35029
W124
P
S
K
R
K
R
H
W
R
P
Y
L
E
L
S
Rhesus Macaque
Macaca mulatta
XP_001115260
359
40552
S158
K
K
H
R
R
R
P
S
K
K
K
R
H
W
K
Dog
Lupus familis
XP_848322
303
34138
K119
Y
K
L
T
W
E
E
K
K
K
F
D
E
K
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8R409
356
40225
S155
K
K
H
R
R
R
P
S
K
K
K
R
H
W
K
Rat
Rattus norvegicus
Q5M9G1
356
40299
S155
K
K
H
R
R
R
P
S
K
K
K
R
H
W
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512237
286
31342
N102
P
R
T
L
L
D
P
N
D
P
W
D
V
P
P
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4V7W3
285
32469
L101
T
W
E
E
K
K
E
L
E
E
R
Q
S
Q
R
Zebra Danio
Brachydanio rerio
A5D8S8
319
36200
T131
K
E
L
D
E
R
E
T
A
R
A
S
R
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_792438
230
26777
R46
R
K
R
R
R
P
R
R
K
N
R
K
W
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
37.3
98
76
N.A.
85.7
85.5
N.A.
40.1
N.A.
42.9
46.5
N.A.
N.A.
N.A.
N.A.
25.3
Protein Similarity:
100
50.7
98.3
77.9
N.A.
89.1
88.8
N.A.
49.8
N.A.
55.9
62.9
N.A.
N.A.
N.A.
N.A.
39.5
P-Site Identity:
100
13.3
100
20
N.A.
100
100
N.A.
6.6
N.A.
0
13.3
N.A.
N.A.
N.A.
N.A.
26.6
P-Site Similarity:
100
26.6
100
26.6
N.A.
100
100
N.A.
20
N.A.
46.6
40
N.A.
N.A.
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
10
0
0
10
0
0
20
0
0
0
% D
% Glu:
0
10
10
10
10
10
30
0
10
10
0
0
20
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
40
0
0
0
10
0
0
0
0
0
40
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
50
60
10
0
20
10
0
10
60
50
40
10
0
20
40
% K
% Leu:
0
0
20
10
10
0
0
10
0
0
0
10
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
0
% N
% Pro:
20
0
0
0
0
10
50
0
0
20
0
0
0
10
20
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
10
% Q
% Arg:
10
10
10
60
50
60
10
10
10
10
20
40
10
0
20
% R
% Ser:
0
10
0
0
0
0
0
40
0
0
0
10
10
0
10
% S
% Thr:
10
0
10
10
0
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% V
% Trp:
0
10
0
0
10
0
0
10
0
0
10
0
10
40
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _