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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIRAS1
All Species:
22.12
Human Site:
S174
Identified Species:
37.44
UniProt:
O95057
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95057
NP_660156.1
198
22329
S174
L
E
T
R
R
N
M
S
L
N
I
D
G
K
R
Chimpanzee
Pan troglodytes
XP_001142084
196
21944
V173
L
T
G
E
R
E
D
V
E
S
L
S
Q
G
E
Rhesus Macaque
Macaca mulatta
XP_001099006
198
22268
S174
L
E
T
R
R
N
M
S
L
N
I
D
G
K
R
Dog
Lupus familis
XP_542186
198
22352
S174
L
E
T
R
R
N
M
S
L
N
I
D
G
K
R
Cat
Felis silvestris
Mouse
Mus musculus
Q91Z61
198
22246
S174
L
E
T
R
R
S
V
S
L
S
V
D
G
K
R
Rat
Rattus norvegicus
Q62636
184
20779
L161
V
N
E
I
F
Y
D
L
V
R
Q
I
N
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515276
297
31728
A241
L
E
K
X
K
T
L
A
L
S
L
P
L
S
A
Chicken
Gallus gallus
XP_423026
199
22563
S175
L
E
K
R
R
T
V
S
L
Q
I
D
G
K
K
Frog
Xenopus laevis
Q7ZXH7
184
20815
L161
V
N
E
I
F
Y
D
L
V
R
Q
I
N
R
K
Zebra Danio
Brachydanio rerio
Q6TEN1
184
20809
L161
V
N
E
I
F
Y
D
L
V
R
Q
I
N
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P08645
184
20845
V161
N
D
I
F
Y
D
L
V
R
Q
I
N
K
K
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780973
198
22635
S174
L
E
K
R
R
T
M
S
L
H
L
E
T
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13856
272
30372
N249
V
P
K
S
G
S
S
N
R
T
G
I
S
A
T
Red Bread Mold
Neurospora crassa
Q01387
229
25331
S205
T
P
R
A
L
P
P
S
G
N
S
K
S
E
K
Conservation
Percent
Protein Identity:
100
71.7
99.4
97.4
N.A.
93.9
39.9
N.A.
55.2
79.9
39.9
39.9
N.A.
39.3
N.A.
N.A.
74.7
Protein Similarity:
100
84.3
99.4
98.9
N.A.
97.4
64.1
N.A.
60.9
90.9
64.1
64.6
N.A.
64.1
N.A.
N.A.
87.8
P-Site Identity:
100
13.3
100
100
N.A.
73.3
0
N.A.
20
66.6
0
0
N.A.
13.3
N.A.
N.A.
53.3
P-Site Similarity:
100
26.6
100
100
N.A.
100
26.6
N.A.
53.3
80
26.6
26.6
N.A.
40
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.4
33.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.8
51.9
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
0
0
0
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
8
29
0
0
0
0
36
0
0
0
% D
% Glu:
0
50
22
8
0
8
0
0
8
0
0
8
0
8
8
% E
% Phe:
0
0
0
8
22
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
8
0
0
0
8
0
8
0
36
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
8
22
0
0
0
0
0
0
36
29
0
0
0
% I
% Lys:
0
0
29
0
8
0
0
0
0
0
0
8
8
50
43
% K
% Leu:
58
0
0
0
8
0
15
22
50
0
22
0
8
0
0
% L
% Met:
0
0
0
0
0
0
29
0
0
0
0
0
0
0
0
% M
% Asn:
8
22
0
0
0
22
0
8
0
29
0
8
22
0
0
% N
% Pro:
0
15
0
0
0
8
8
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
15
22
0
8
0
0
% Q
% Arg:
0
0
8
43
50
0
0
0
15
22
0
0
0
22
29
% R
% Ser:
0
0
0
8
0
15
8
50
0
22
8
8
15
8
8
% S
% Thr:
8
8
29
0
0
22
0
0
0
8
0
0
8
0
8
% T
% Val:
29
0
0
0
0
0
15
15
22
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
22
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _