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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-2
All Species:
40.3
Human Site:
S154
Identified Species:
80.61
UniProt:
O95096
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95096
NP_002500.1
273
30133
S154
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Chimpanzee
Pan troglodytes
XP_519662
366
38728
S223
F
K
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542867
273
30061
S154
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Cat
Felis silvestris
Mouse
Mus musculus
P42586
273
30107
S154
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Rat
Rattus norvegicus
P23441
372
38536
S187
F
K
Q
Q
K
Y
L
S
A
P
E
R
E
H
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
S145
F
K
Q
Q
K
Y
L
S
A
P
E
R
D
H
L
Frog
Xenopus laevis
P42587
196
22791
Q91
L
E
R
R
F
R
Q
Q
R
Y
L
S
A
P
E
Zebra Danio
Brachydanio rerio
Q90481
269
30288
S151
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
S571
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Honey Bee
Apis mellifera
XP_001121493
260
29654
E143
A
N
E
I
Q
P
H
E
T
E
H
K
K
R
K
Nematode Worm
Caenorhab. elegans
P41936
346
37493
S215
F
R
S
Q
K
Y
L
S
A
P
E
R
E
A
L
Sea Urchin
Strong. purpuratus
NP_001123283
437
46696
S268
F
R
Q
Q
R
Y
L
S
A
P
E
R
E
H
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
34.1
N.A.
99.2
N.A.
98.1
32.7
N.A.
N.A.
36.3
54.2
83.8
N.A.
24.8
40.6
29.1
35.7
Protein Similarity:
100
42.9
N.A.
99.6
N.A.
99.2
43.2
N.A.
N.A.
53
60.4
89.3
N.A.
29.3
51.2
42.7
46.2
P-Site Identity:
100
93.3
N.A.
100
N.A.
100
86.6
N.A.
N.A.
80
0
100
N.A.
100
0
80
100
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
N.A.
100
13.3
100
N.A.
100
26.6
86.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
0
84
0
0
0
9
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% D
% Glu:
0
9
9
0
0
0
0
9
0
9
84
0
75
0
9
% E
% Phe:
84
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
9
0
0
0
9
0
0
75
0
% H
% Ile:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
25
0
0
25
0
0
0
0
0
0
9
9
0
9
% K
% Leu:
9
0
0
0
0
0
84
0
0
0
9
0
0
0
84
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
9
0
0
0
84
0
0
0
9
0
% P
% Gln:
0
0
75
84
9
0
9
9
0
0
0
0
0
0
0
% Q
% Arg:
0
59
9
9
59
9
0
0
9
0
0
84
0
9
0
% R
% Ser:
0
0
9
0
0
0
0
84
0
0
0
9
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
84
0
0
0
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _