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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-2
All Species:
12.73
Human Site:
T118
Identified Species:
25.45
UniProt:
O95096
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95096
NP_002500.1
273
30133
T118
S
P
D
N
D
K
E
T
P
G
G
G
G
D
A
Chimpanzee
Pan troglodytes
XP_519662
366
38728
P173
L
G
G
G
A
R
V
P
E
R
G
V
G
N
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542867
273
30061
T118
S
P
D
N
D
K
E
T
P
G
G
G
G
D
A
Cat
Felis silvestris
Mouse
Mus musculus
P42586
273
30107
T118
S
P
D
N
D
K
E
T
Q
G
G
G
G
D
A
Rat
Rattus norvegicus
P23441
372
38536
G110
T
M
R
N
S
A
S
G
P
G
W
Y
G
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
R106
K
S
L
E
Q
E
K
R
E
L
E
D
P
E
R
Frog
Xenopus laevis
P42587
196
22791
K58
D
E
S
P
D
N
D
K
E
L
S
S
N
P
D
Zebra Danio
Brachydanio rerio
Q90481
269
30288
S117
D
N
D
K
E
T
S
S
N
G
S
D
S
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
S495
T
T
N
N
N
N
H
S
L
K
A
E
G
I
N
Honey Bee
Apis mellifera
XP_001121493
260
29654
S102
N
V
L
Q
Q
P
D
S
T
S
P
T
I
S
D
Nematode Worm
Caenorhab. elegans
P41936
346
37493
I163
N
K
S
D
K
D
G
I
K
L
E
D
E
D
E
Sea Urchin
Strong. purpuratus
NP_001123283
437
46696
A219
D
D
D
L
D
S
V
A
S
D
K
D
G
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
34.1
N.A.
99.2
N.A.
98.1
32.7
N.A.
N.A.
36.3
54.2
83.8
N.A.
24.8
40.6
29.1
35.7
Protein Similarity:
100
42.9
N.A.
99.6
N.A.
99.2
43.2
N.A.
N.A.
53
60.4
89.3
N.A.
29.3
51.2
42.7
46.2
P-Site Identity:
100
13.3
N.A.
100
N.A.
93.3
26.6
N.A.
N.A.
0
6.6
13.3
N.A.
13.3
0
6.6
26.6
P-Site Similarity:
100
33.3
N.A.
100
N.A.
93.3
33.3
N.A.
N.A.
20
13.3
26.6
N.A.
40
20
20
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
9
0
9
0
0
9
0
0
9
25
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
25
9
42
9
42
9
17
0
0
9
0
34
0
42
17
% D
% Glu:
0
9
0
9
9
9
25
0
25
0
17
9
9
9
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
9
9
0
0
9
9
0
42
34
25
59
9
0
% G
% His:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
9
0
0
0
0
9
9
0
% I
% Lys:
9
9
0
9
9
25
9
9
9
9
9
0
0
0
9
% K
% Leu:
9
0
17
9
0
0
0
0
9
25
0
0
0
0
0
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
17
9
9
42
9
17
0
0
9
0
0
0
9
9
17
% N
% Pro:
0
25
0
9
0
9
0
9
25
0
9
0
9
9
0
% P
% Gln:
0
0
0
9
17
0
0
0
9
0
0
0
0
0
0
% Q
% Arg:
0
0
9
0
0
9
0
9
0
9
0
0
0
0
9
% R
% Ser:
25
9
17
0
9
9
17
25
9
9
17
9
9
9
17
% S
% Thr:
17
9
0
0
0
9
0
25
9
0
0
9
0
0
0
% T
% Val:
0
9
0
0
0
0
17
0
0
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _