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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NKX2-2 All Species: 15.45
Human Site: Y237 Identified Species: 30.91
UniProt: O95096 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95096 NP_002500.1 273 30133 Y237 A G I P F S A Y S A Q S L Q H
Chimpanzee Pan troglodytes XP_519662 366 38728 Y309 A V S P Y S C Y G G Y S G A P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542867 273 30061 Y237 A G I P F S A Y S A Q S L Q H
Cat Felis silvestris
Mouse Mus musculus P42586 273 30107 Y237 A G I P F S A Y S A Q S L Q H
Rat Rattus norvegicus P23441 372 38536 A336 P D L A H H A A S P A A L Q G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90788 294 33054 N222 S P Y N V S I N P Y S Y N A Y
Frog Xenopus laevis P42587 196 22791 A161 K P C H T L K A Q D F N P A T
Zebra Danio Brachydanio rerio Q90481 269 30288 Y233 A G I P F S A Y S A Q S L Q H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P22808 723 76404 H675 A M Q N A A A H H L V A L N G
Honey Bee Apis mellifera XP_001121493 260 29654 P217 A S G S G C S P R R V A V P L
Nematode Worm Caenorhab. elegans P41936 346 37493 F305 T S P Y T V A F G S A N S G Y
Sea Urchin Strong. purpuratus NP_001123283 437 46696 A361 A A S A C M S A A A K S H H H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 34.1 N.A. 99.2 N.A. 98.1 32.7 N.A. N.A. 36.3 54.2 83.8 N.A. 24.8 40.6 29.1 35.7
Protein Similarity: 100 42.9 N.A. 99.6 N.A. 99.2 43.2 N.A. N.A. 53 60.4 89.3 N.A. 29.3 51.2 42.7 46.2
P-Site Identity: 100 33.3 N.A. 100 N.A. 100 26.6 N.A. N.A. 6.6 0 100 N.A. 20 6.6 6.6 26.6
P-Site Similarity: 100 40 N.A. 100 N.A. 100 40 N.A. N.A. 20 6.6 100 N.A. 40 26.6 33.3 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 67 9 0 17 9 9 59 25 9 42 17 25 0 25 0 % A
% Cys: 0 0 9 0 9 9 9 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 0 0 0 0 0 9 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 34 0 0 9 0 0 9 0 0 0 0 % F
% Gly: 0 34 9 0 9 0 0 0 17 9 0 0 9 9 17 % G
% His: 0 0 0 9 9 9 0 9 9 0 0 0 9 9 42 % H
% Ile: 0 0 34 0 0 0 9 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 0 0 0 0 9 0 0 0 9 0 0 0 0 % K
% Leu: 0 0 9 0 0 9 0 0 0 9 0 0 50 0 9 % L
% Met: 0 9 0 0 0 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 17 0 0 0 9 0 0 0 17 9 9 0 % N
% Pro: 9 17 9 42 0 0 0 9 9 9 0 0 9 9 9 % P
% Gln: 0 0 9 0 0 0 0 0 9 0 34 0 0 42 0 % Q
% Arg: 0 0 0 0 0 0 0 0 9 9 0 0 0 0 0 % R
% Ser: 9 17 17 9 0 50 17 0 42 9 9 50 9 0 0 % S
% Thr: 9 0 0 0 17 0 0 0 0 0 0 0 0 0 9 % T
% Val: 0 9 0 0 9 9 0 0 0 0 17 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 9 9 0 0 42 0 9 9 9 0 0 17 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _