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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-2
All Species:
16.06
Human Site:
Y251
Identified Species:
32.12
UniProt:
O95096
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95096
NP_002500.1
273
30133
Y251
H
M
Q
Y
N
A
Q
Y
S
S
A
S
T
P
Q
Chimpanzee
Pan troglodytes
XP_519662
366
38728
T323
P
Y
G
A
G
Y
G
T
C
Y
A
G
A
P
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542867
273
30061
Y251
H
M
Q
Y
N
A
Q
Y
S
S
A
S
T
P
Q
Cat
Felis silvestris
Mouse
Mus musculus
P42586
273
30107
Y251
H
M
Q
Y
N
A
Q
Y
S
S
A
S
T
P
Q
Rat
Rattus norvegicus
P23441
372
38536
H350
G
Q
V
S
S
L
S
H
L
N
S
S
G
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
N236
Y
P
A
Y
P
N
Y
N
S
P
A
C
N
A
N
Frog
Xenopus laevis
P42587
196
22791
F175
T
F
P
T
G
I
P
F
S
A
Y
S
A
Q
S
Zebra Danio
Brachydanio rerio
Q90481
269
30288
Y247
H
M
Q
Y
N
A
H
Y
S
A
A
T
T
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
A689
G
A
A
A
Y
Q
H
A
A
A
A
A
A
G
L
Honey Bee
Apis mellifera
XP_001121493
260
29654
P231
L
L
I
K
D
G
K
P
C
Q
S
K
L
M
E
Nematode Worm
Caenorhab. elegans
P41936
346
37493
Y319
Y
L
P
T
P
S
A
Y
L
P
A
T
S
G
Y
Sea Urchin
Strong. purpuratus
NP_001123283
437
46696
D375
H
H
H
H
H
H
Q
D
S
M
L
A
S
S
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
34.1
N.A.
99.2
N.A.
98.1
32.7
N.A.
N.A.
36.3
54.2
83.8
N.A.
24.8
40.6
29.1
35.7
Protein Similarity:
100
42.9
N.A.
99.6
N.A.
99.2
43.2
N.A.
N.A.
53
60.4
89.3
N.A.
29.3
51.2
42.7
46.2
P-Site Identity:
100
13.3
N.A.
100
N.A.
100
6.6
N.A.
N.A.
20
13.3
80
N.A.
6.6
0
13.3
20
P-Site Similarity:
100
13.3
N.A.
100
N.A.
100
33.3
N.A.
N.A.
26.6
26.6
93.3
N.A.
26.6
33.3
46.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
17
17
0
34
9
9
9
25
67
17
25
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
17
0
0
9
0
0
0
% C
% Asp:
0
0
0
0
9
0
0
9
0
0
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% E
% Phe:
0
9
0
0
0
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
17
0
9
0
17
9
9
0
0
0
0
9
9
17
0
% G
% His:
42
9
9
9
9
9
17
9
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
9
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
9
0
0
9
0
0
0
0
9
0
0
0
% K
% Leu:
9
17
0
0
0
9
0
0
17
0
9
0
9
0
9
% L
% Met:
0
34
0
0
0
0
0
0
0
9
0
0
0
9
0
% M
% Asn:
0
0
0
0
34
9
0
9
0
9
0
0
9
0
9
% N
% Pro:
9
9
17
0
17
0
9
9
0
17
0
0
0
42
0
% P
% Gln:
0
9
34
0
0
9
34
0
0
9
0
0
0
9
34
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
9
9
9
9
0
59
25
17
42
17
17
17
% S
% Thr:
9
0
0
17
0
0
0
9
0
0
0
17
34
0
0
% T
% Val:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
17
9
0
42
9
9
9
42
0
9
9
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _