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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-2
All Species:
12.42
Human Site:
Y259
Identified Species:
24.85
UniProt:
O95096
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95096
NP_002500.1
273
30133
Y259
S
S
A
S
T
P
Q
Y
P
T
A
H
P
L
V
Chimpanzee
Pan troglodytes
XP_519662
366
38728
G331
C
Y
A
G
A
P
S
G
P
A
P
H
T
P
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542867
273
30061
Y259
S
S
A
S
T
P
Q
Y
P
T
A
H
P
L
V
Cat
Felis silvestris
Mouse
Mus musculus
P42586
273
30107
Y259
S
S
A
S
T
P
Q
Y
P
T
A
H
P
L
V
Rat
Rattus norvegicus
P23441
372
38536
Y358
L
N
S
S
G
S
D
Y
G
A
M
S
C
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
Y244
S
P
A
C
N
A
N
Y
N
C
S
Y
P
A
V
Frog
Xenopus laevis
P42587
196
22791
L183
S
A
Y
S
A
Q
S
L
H
H
M
Q
Y
N
A
Zebra Danio
Brachydanio rerio
Q90481
269
30288
F255
S
A
A
T
T
P
Q
F
P
T
A
H
H
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
H697
A
A
A
A
A
G
L
H
A
H
A
H
A
H
A
Honey Bee
Apis mellifera
XP_001121493
260
29654
P239
C
Q
S
K
L
M
E
P
A
T
Y
P
A
T
G
Nematode Worm
Caenorhab. elegans
P41936
346
37493
F327
L
P
A
T
S
G
Y
F
S
N
G
P
S
A
A
Sea Urchin
Strong. purpuratus
NP_001123283
437
46696
A383
S
M
L
A
S
S
A
A
V
T
A
P
Q
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
34.1
N.A.
99.2
N.A.
98.1
32.7
N.A.
N.A.
36.3
54.2
83.8
N.A.
24.8
40.6
29.1
35.7
Protein Similarity:
100
42.9
N.A.
99.6
N.A.
99.2
43.2
N.A.
N.A.
53
60.4
89.3
N.A.
29.3
51.2
42.7
46.2
P-Site Identity:
100
26.6
N.A.
100
N.A.
100
13.3
N.A.
N.A.
33.3
13.3
73.3
N.A.
20
6.6
6.6
20
P-Site Similarity:
100
33.3
N.A.
100
N.A.
100
26.6
N.A.
N.A.
46.6
20
93.3
N.A.
46.6
20
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
25
67
17
25
9
9
9
17
17
50
0
17
17
25
% A
% Cys:
17
0
0
9
0
0
0
0
0
9
0
0
9
0
0
% C
% Asp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
17
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
9
9
17
0
9
9
0
9
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
9
9
17
0
50
9
9
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
17
0
9
0
9
0
9
9
0
0
0
0
0
34
17
% L
% Met:
0
9
0
0
0
9
0
0
0
0
17
0
0
0
0
% M
% Asn:
0
9
0
0
9
0
9
0
9
9
0
0
0
9
0
% N
% Pro:
0
17
0
0
0
42
0
9
42
0
9
25
34
9
0
% P
% Gln:
0
9
0
0
0
9
34
0
0
0
0
9
9
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
59
25
17
42
17
17
17
0
9
0
9
9
9
17
0
% S
% Thr:
0
0
0
17
34
0
0
0
0
50
0
0
9
9
9
% T
% Val:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
42
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
9
0
0
0
9
42
0
0
9
9
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _