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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-2
All Species:
14.24
Human Site:
Y66
Identified Species:
28.48
UniProt:
O95096
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95096
NP_002500.1
273
30133
Y66
L
P
L
K
N
P
F
Y
D
S
S
D
N
P
Y
Chimpanzee
Pan troglodytes
XP_519662
366
38728
H121
E
P
R
G
S
E
V
H
N
A
G
G
G
G
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542867
273
30061
Y66
L
P
L
K
N
P
F
Y
D
S
S
D
N
P
Y
Cat
Felis silvestris
Mouse
Mus musculus
P42586
273
30107
Y66
L
P
L
K
S
P
F
Y
D
S
S
D
N
P
Y
Rat
Rattus norvegicus
P23441
372
38536
V58
A
A
M
Q
Q
H
A
V
G
H
H
G
A
V
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
L54
F
G
S
E
P
P
A
L
P
E
L
P
E
P
P
Frog
Xenopus laevis
P42587
196
22791
Zebra Danio
Brachydanio rerio
Q90481
269
30288
Y65
L
P
L
K
N
P
F
Y
D
N
S
D
N
P
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
K443
P
A
L
S
G
D
Y
K
S
Y
S
R
S
A
D
Honey Bee
Apis mellifera
XP_001121493
260
29654
T50
Y
Q
Q
F
F
E
H
T
T
A
M
L
Q
P
A
Nematode Worm
Caenorhab. elegans
P41936
346
37493
P111
T
P
T
F
S
F
D
P
C
T
Y
G
S
Y
D
Sea Urchin
Strong. purpuratus
NP_001123283
437
46696
W167
S
D
N
P
Y
T
R
W
L
Q
T
Q
G
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
34.1
N.A.
99.2
N.A.
98.1
32.7
N.A.
N.A.
36.3
54.2
83.8
N.A.
24.8
40.6
29.1
35.7
Protein Similarity:
100
42.9
N.A.
99.6
N.A.
99.2
43.2
N.A.
N.A.
53
60.4
89.3
N.A.
29.3
51.2
42.7
46.2
P-Site Identity:
100
6.6
N.A.
100
N.A.
93.3
0
N.A.
N.A.
13.3
0
93.3
N.A.
13.3
6.6
6.6
0
P-Site Similarity:
100
33.3
N.A.
100
N.A.
100
13.3
N.A.
N.A.
20
0
100
N.A.
26.6
13.3
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
17
0
0
0
0
17
0
0
17
0
0
9
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
9
9
0
34
0
0
34
0
0
25
% D
% Glu:
9
0
0
9
0
17
0
0
0
9
0
0
9
0
0
% E
% Phe:
9
0
0
17
9
9
34
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
9
9
0
0
0
9
0
9
25
17
17
9
% G
% His:
0
0
0
0
0
9
9
9
0
9
9
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
34
0
0
0
9
0
0
0
0
0
0
0
% K
% Leu:
34
0
42
0
0
0
0
9
9
0
9
9
0
0
0
% L
% Met:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% M
% Asn:
0
0
9
0
25
0
0
0
9
9
0
0
34
0
0
% N
% Pro:
9
50
0
9
9
42
0
9
9
0
0
9
0
50
9
% P
% Gln:
0
9
9
9
9
0
0
0
0
9
0
9
9
0
0
% Q
% Arg:
0
0
9
0
0
0
9
0
0
0
0
9
0
0
0
% R
% Ser:
9
0
9
9
25
0
0
0
9
25
42
0
17
0
0
% S
% Thr:
9
0
9
0
0
9
0
9
9
9
9
0
0
0
9
% T
% Val:
0
0
0
0
0
0
9
9
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
9
0
9
34
0
9
9
0
0
9
34
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _