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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE4B All Species: 21.21
Human Site: S486 Identified Species: 35.9
UniProt: O95155 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95155 NP_001099032.1 1302 146185 S486 P R S L Q Q P S F L V P Y M L
Chimpanzee Pan troglodytes XP_001161430 1302 146197 S486 P R S L Q Q P S F L V P Y M L
Rhesus Macaque Macaca mulatta XP_001101836 1302 146120 S486 P R S L Q Q P S F L V P Y M L
Dog Lupus familis XP_849824 1312 147260 S496 P R S M Q Q P S F L V P Y M L
Cat Felis silvestris
Mouse Mus musculus Q9ES00 1173 133285 P441 C N L V A S L P L W L P K S L
Rat Rattus norvegicus Q6P7A2 1066 122361 L334 K T L L G V I L N I S C L L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515124 1303 145844 S487 P R S G Q Q Q S L L V P Y M L
Chicken Gallus gallus XP_417607 1324 149015 S508 P R S L Q Q Q S L L V P Y M L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_919343 1183 134341 P451 C N L I T S L P L W C P D P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609597 1217 138573 G476 K L V V I K V G S V R P I A D
Honey Bee Apis mellifera XP_395681 1103 125977 Q371 I C R L I V H Q I Q F L P D I
Nematode Worm Caenorhab. elegans Q09349 980 113212 R248 R L P S N G P R P L S N L L V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LF41 1038 117510 F306 P A D L L S S F S T I K N F M
Baker's Yeast Sacchar. cerevisiae P54860 961 109887 A229 S L S P I E A A V A I R N Y G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99.7 95.9 N.A. 88 21.6 N.A. 90.9 86.9 N.A. 73.6 N.A. 33.5 39.6 24.2 N.A.
Protein Similarity: 100 99.8 99.8 96.6 N.A. 89.3 38.7 N.A. 93.3 91.4 N.A. 82 N.A. 52.8 57.5 41.7 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 13.3 6.6 N.A. 80 86.6 N.A. 13.3 N.A. 6.6 6.6 13.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 26.6 20 N.A. 80 86.6 N.A. 20 N.A. 26.6 13.3 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.9 23.1 N.A.
Protein Similarity: N.A. N.A. N.A. 42.9 39.9 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 8 0 8 8 0 8 0 0 0 8 0 % A
% Cys: 15 8 0 0 0 0 0 0 0 0 8 8 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 0 0 0 0 0 8 8 8 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 8 29 0 8 0 0 8 0 % F
% Gly: 0 0 0 8 8 8 0 8 0 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 8 22 0 8 0 8 8 15 0 8 0 8 % I
% Lys: 15 0 0 0 0 8 0 0 0 0 0 8 8 0 8 % K
% Leu: 0 22 22 50 8 0 15 8 29 50 8 8 15 15 58 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 43 8 % M
% Asn: 0 15 0 0 8 0 0 0 8 0 0 8 15 0 0 % N
% Pro: 50 0 8 8 0 0 36 15 8 0 0 65 8 8 0 % P
% Gln: 0 0 0 0 43 43 15 8 0 8 0 0 0 0 0 % Q
% Arg: 8 43 8 0 0 0 0 8 0 0 8 8 0 0 0 % R
% Ser: 8 0 50 8 0 22 8 43 15 0 15 0 0 8 0 % S
% Thr: 0 8 0 0 8 0 0 0 0 8 0 0 0 0 0 % T
% Val: 0 0 8 15 0 15 8 0 8 8 43 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 43 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _