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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KIF4A All Species: 14.55
Human Site: S1186 Identified Species: 21.33
UniProt: O95239 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95239 NP_036442.3 1232 139881 S1186 K K T P P A P S P F D L P E L
Chimpanzee Pan troglodytes XP_518055 1227 139177 S1181 K K T A P A P S P F D L P E S
Rhesus Macaque Macaca mulatta XP_001084213 1234 139742 S1188 K K T P P A P S L F D L P E L
Dog Lupus familis XP_549061 1234 139874 S1188 K K T T P A A S S F G L L E L
Cat Felis silvestris
Mouse Mus musculus P33174 1231 139533 S1186 K Q P M F V S S S D H P E L K
Rat Rattus norvegicus Q7M6Z5 1394 158861 P1341 P P P P Q L Q P V R S I A Q L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90640 1225 138905 K1178 D Q G V F M K K P S T A A S L
Frog Xenopus laevis Q91784 1226 138905 S1182 I K L Q R K P S T A S A S A S
Zebra Danio Brachydanio rerio Q58G59 1363 154819 N1311 R A A C E L P N N R I V Q P G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46867 784 88189 R740 G S S I P N V R N I K S S R G
Honey Bee Apis mellifera XP_395595 1064 123475 I1020 R T L F V E N I E E E R E K C
Nematode Worm Caenorhab. elegans P46873 699 78760 T655 K S D Q K L S T S K S L F P S
Sea Urchin Strong. purpuratus P46872 699 78679 N655 S N V F L T Y N L E G G G M K
Poplar Tree Populus trichocarpa XP_002302432 1055 118553 Q1002 R K L A V V G Q G G K L W R W
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_199593 1035 116715 S991 R L W R W K R S H H Q W I V Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa P48467 928 102392 G884 G L G G F S I G S R I A K P L
Conservation
Percent
Protein Identity: 100 93.1 96.4 94.8 N.A. 87 27 N.A. N.A. 74.5 68.5 25.8 N.A. 26.9 36.8 27.1 27.3
Protein Similarity: 100 95.6 97.2 97 N.A. 92.7 47.6 N.A. N.A. 85.9 82.1 45.1 N.A. 41.4 56.3 38.4 39.3
P-Site Identity: 100 86.6 93.3 66.6 N.A. 13.3 13.3 N.A. N.A. 13.3 20 6.6 N.A. 6.6 0 13.3 0
P-Site Similarity: 100 86.6 93.3 66.6 N.A. 20 26.6 N.A. N.A. 20 20 26.6 N.A. 13.3 20 20 6.6
Percent
Protein Identity: 33.2 N.A. N.A. 32.7 N.A. 26.7
Protein Similarity: 51 N.A. N.A. 51 N.A. 44.5
P-Site Identity: 13.3 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 20 N.A. N.A. 13.3 N.A. 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 13 0 25 7 0 0 7 0 19 13 7 0 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 7 0 7 0 0 0 0 0 0 7 19 0 0 0 0 % D
% Glu: 0 0 0 0 7 7 0 0 7 13 7 0 13 25 0 % E
% Phe: 0 0 0 13 19 0 0 0 0 25 0 0 7 0 0 % F
% Gly: 13 0 13 7 0 0 7 7 7 7 13 7 7 0 13 % G
% His: 0 0 0 0 0 0 0 0 7 7 7 0 0 0 0 % H
% Ile: 7 0 0 7 0 0 7 7 0 7 13 7 7 0 0 % I
% Lys: 38 38 0 0 7 13 7 7 0 7 13 0 7 7 13 % K
% Leu: 0 13 19 0 7 19 0 0 13 0 0 38 7 7 38 % L
% Met: 0 0 0 7 0 7 0 0 0 0 0 0 0 7 0 % M
% Asn: 0 7 0 0 0 7 7 13 13 0 0 0 0 0 0 % N
% Pro: 7 7 13 19 32 0 32 7 19 0 0 7 19 19 0 % P
% Gln: 0 13 0 13 7 0 7 7 0 0 7 0 7 7 7 % Q
% Arg: 25 0 0 7 7 0 7 7 0 19 0 7 0 13 0 % R
% Ser: 7 13 7 0 0 7 13 44 25 7 19 7 13 7 19 % S
% Thr: 0 7 25 7 0 7 0 7 7 0 7 0 0 0 0 % T
% Val: 0 0 7 7 13 13 7 0 7 0 0 7 0 7 0 % V
% Trp: 0 0 7 0 7 0 0 0 0 0 0 7 7 0 7 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _