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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCC6 All Species: 24.85
Human Site: S245 Identified Species: 49.7
UniProt: O95255 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95255 NP_001162.4 1503 164906 S245 S L G R E N S S E E L V S R L
Chimpanzee Pan troglodytes XP_001145351 1247 137800 A114 I G A V Y R K A L V I T N S A
Rhesus Macaque Macaca mulatta XP_001109862 1347 147568 A214 G A S F P S K A M F W W V S G
Dog Lupus familis XP_547113 1504 165780 S245 S L G R E N S S E E L V S Q L
Cat Felis silvestris
Mouse Mus musculus Q9R1S7 1498 164770 S251 S L G R E N S S E E L V S Q L
Rat Rattus norvegicus O88269 1502 164977 S251 S L E R E N S S E E L V S Q L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517193 1537 172363 S262 S L N R E D T S D Q V V P V L
Chicken Gallus gallus Q5F364 1525 170953 S250 S L N K E D T S E E I V P G L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001341895 1518 169232 S250 S L N N E D K S E R V V P Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91660 1290 143990 V157 H V C F K M R V A M G S M I F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LZJ5 1539 172119 N246 V V V E K S E N V S L Y A S A
Baker's Yeast Sacchar. cerevisiae P39109 1515 171103 Y244 Y L V E A D L Y K L P R N F S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 39.6 84.9 79.5 N.A. 78.5 78.4 N.A. 45 45.3 N.A. 45.9 N.A. 28.2 N.A. N.A. N.A.
Protein Similarity: 100 55.6 86.8 87.3 N.A. 85.8 86 N.A. 63.5 63.2 N.A. 64.1 N.A. 46.9 N.A. N.A. N.A.
P-Site Identity: 100 0 0 93.3 N.A. 93.3 86.6 N.A. 46.6 53.3 N.A. 46.6 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 20 13.3 100 N.A. 100 93.3 N.A. 80 80 N.A. 66.6 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.9 33.8 N.A.
Protein Similarity: N.A. N.A. N.A. 49.5 52.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 0 9 0 0 17 9 0 0 0 9 0 17 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 34 0 0 9 0 0 0 0 0 0 % D
% Glu: 0 0 9 17 59 0 9 0 50 42 0 0 0 0 0 % E
% Phe: 0 0 0 17 0 0 0 0 0 9 0 0 0 9 9 % F
% Gly: 9 9 25 0 0 0 0 0 0 0 9 0 0 9 9 % G
% His: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 0 0 0 0 17 0 0 9 0 % I
% Lys: 0 0 0 9 17 0 25 0 9 0 0 0 0 0 0 % K
% Leu: 0 67 0 0 0 0 9 0 9 9 42 0 0 0 59 % L
% Met: 0 0 0 0 0 9 0 0 9 9 0 0 9 0 0 % M
% Asn: 0 0 25 9 0 34 0 9 0 0 0 0 17 0 0 % N
% Pro: 0 0 0 0 9 0 0 0 0 0 9 0 25 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 9 0 0 0 34 0 % Q
% Arg: 0 0 0 42 0 9 9 0 0 9 0 9 0 9 0 % R
% Ser: 59 0 9 0 0 17 34 59 0 9 0 9 34 25 9 % S
% Thr: 0 0 0 0 0 0 17 0 0 0 0 9 0 0 0 % T
% Val: 9 17 17 9 0 0 0 9 9 9 17 59 9 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % W
% Tyr: 9 0 0 0 9 0 0 9 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _