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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KCNH1 All Species: 22.42
Human Site: S435 Identified Species: 49.33
UniProt: O95259 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95259 NP_002229.1 989 111423 S435 T P Y Q F N G S G S G K W E G
Chimpanzee Pan troglodytes XP_001169423 962 108518 S418 G K W E G G P S K N S V Y I S
Rhesus Macaque Macaca mulatta XP_001109251 989 111413 S435 T P Y Q F N G S G S G K W E G
Dog Lupus familis XP_848926 993 110869 S435 T P Y Q F N G S G S G K W E G
Cat Felis silvestris
Mouse Mus musculus Q60603 989 111295 S435 T P Y Q F N G S G S G K W E G
Rat Rattus norvegicus Q63472 962 108273 S418 G K W E G G P S K N S V Y I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509629 988 111281 S435 T P Y Q F N L S G S G K W E G
Chicken Gallus gallus Q9PT84 526 59775 K62 I E I I A P H K V T E R T Q N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_697175 956 107906 P415 S G K W E G G P S K D S V Y I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q02280 1174 126352 D425 Y S Y I W S N D T G P E L V N
Honey Bee Apis mellifera XP_625212 1139 127116 S433 S Y L W T N T S T A P E L V A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.9 99.3 91.3 N.A. 97 94.8 N.A. 93.4 23.4 N.A. 78.8 N.A. 47.1 48 N.A. N.A.
Protein Similarity: 100 96.8 99.5 94 N.A. 98 95.8 N.A. 96.5 35.1 N.A. 85.3 N.A. 60.7 62.7 N.A. N.A.
P-Site Identity: 100 6.6 100 100 N.A. 100 6.6 N.A. 93.3 0 N.A. 6.6 N.A. 6.6 13.3 N.A. N.A.
P-Site Similarity: 100 33.3 100 100 N.A. 100 33.3 N.A. 93.3 20 N.A. 13.3 N.A. 26.6 33.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 10 0 0 10 0 0 0 0 % D
% Glu: 0 10 0 19 10 0 0 0 0 0 10 19 0 46 0 % E
% Phe: 0 0 0 0 46 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 19 10 0 0 19 28 46 0 46 10 46 0 0 0 46 % G
% His: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 10 19 0 0 0 0 0 0 0 0 0 19 10 % I
% Lys: 0 19 10 0 0 0 0 10 19 10 0 46 0 0 0 % K
% Leu: 0 0 10 0 0 0 10 0 0 0 0 0 19 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 55 10 0 0 19 0 0 0 0 19 % N
% Pro: 0 46 0 0 0 10 19 10 0 0 19 0 0 0 0 % P
% Gln: 0 0 0 46 0 0 0 0 0 0 0 0 0 10 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % R
% Ser: 19 10 0 0 0 10 0 73 10 46 19 10 0 0 19 % S
% Thr: 46 0 0 0 10 0 10 0 19 10 0 0 10 0 0 % T
% Val: 0 0 0 0 0 0 0 0 10 0 0 19 10 19 0 % V
% Trp: 0 0 19 19 10 0 0 0 0 0 0 0 46 0 0 % W
% Tyr: 10 10 55 0 0 0 0 0 0 0 0 0 19 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _