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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE8B All Species: 4.85
Human Site: T362 Identified Species: 15.24
UniProt: O95263 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95263 NP_001025022.1 885 98979 T362 I Q Q H V K I T P V I G Q G G
Chimpanzee Pan troglodytes XP_517695 907 102819 T384 I Q Q H V K I T P V I G Q G G
Rhesus Macaque Macaca mulatta XP_001101740 752 84621 H273 D N S Q T E P H S F R Y K N R
Dog Lupus familis XP_546056 836 94573 S356 A D N S Q T E S H S F R Y K N
Cat Felis silvestris
Mouse Mus musculus O88502 823 93153 Q344 T D S Q T D N Q A G K H K D R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_413834 859 97059 E363 N K A E K T C E R V Q A E S Q
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001920432 784 88757 H305 S E C N S L R H K D R R K E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9N2V9 760 84862 P281 E M R R K S L P R A R G E E E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.8 81.1 85.6 N.A. 61.1 N.A. N.A. N.A. 68.8 N.A. 69.1 N.A. N.A. N.A. 27.9 N.A.
Protein Similarity: 100 88.9 82.5 88.5 N.A. 75.1 N.A. N.A. N.A. 81.4 N.A. 79.3 N.A. N.A. N.A. 46 N.A.
P-Site Identity: 100 100 0 0 N.A. 0 N.A. N.A. N.A. 6.6 N.A. 0 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 13.3 6.6 N.A. 6.6 N.A. N.A. N.A. 20 N.A. 20 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 13 0 0 0 0 0 13 13 0 13 0 0 0 % A
% Cys: 0 0 13 0 0 0 13 0 0 0 0 0 0 0 0 % C
% Asp: 13 25 0 0 0 13 0 0 0 13 0 0 0 13 0 % D
% Glu: 13 13 0 13 0 13 13 13 0 0 0 0 25 25 13 % E
% Phe: 0 0 0 0 0 0 0 0 0 13 13 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 13 0 38 0 25 25 % G
% His: 0 0 0 25 0 0 0 25 13 0 0 13 0 0 0 % H
% Ile: 25 0 0 0 0 0 25 0 0 0 25 0 0 0 0 % I
% Lys: 0 13 0 0 25 25 0 0 13 0 13 0 38 13 0 % K
% Leu: 0 0 0 0 0 13 13 0 0 0 0 0 0 0 0 % L
% Met: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 13 13 13 13 0 0 13 0 0 0 0 0 0 13 13 % N
% Pro: 0 0 0 0 0 0 13 13 25 0 0 0 0 0 0 % P
% Gln: 0 25 25 25 13 0 0 13 0 0 13 0 25 0 13 % Q
% Arg: 0 0 13 13 0 0 13 0 25 0 38 25 0 0 25 % R
% Ser: 13 0 25 13 13 13 0 13 13 13 0 0 0 13 13 % S
% Thr: 13 0 0 0 25 25 0 25 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 25 0 0 0 0 38 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 13 13 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _