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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR3B
All Species:
5.76
Human Site:
S389
Identified Species:
15.83
UniProt:
O95264
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95264
NP_006019.1
441
50292
S389
W
S
Q
L
Q
S
I
S
N
Y
L
Q
T
Q
D
Chimpanzee
Pan troglodytes
Q5IS51
468
53049
T404
L
D
S
V
R
C
I
T
R
H
I
M
K
E
N
Rhesus Macaque
Macaca mulatta
Q866A2
502
56411
A444
L
E
E
V
R
Y
I
A
N
R
F
R
C
Q
D
Dog
Lupus familis
XP_853967
442
50552
S384
W
F
Q
L
K
S
I
S
T
Y
F
Q
T
W
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHJ5
437
50302
N385
W
F
Q
F
R
S
I
N
N
S
L
R
T
R
D
Rat
Rattus norvegicus
Q9JJ16
437
50317
N385
W
F
Q
L
Q
S
I
N
N
S
L
R
T
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519474
387
44401
R336
Q
E
L
A
A
I
R
R
F
L
E
R
R
E
E
Chicken
Gallus gallus
P22770
502
56928
A444
L
E
E
V
R
Y
I
A
N
R
F
R
D
Q
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_700329
473
53958
R421
L
Q
E
V
M
S
L
R
L
Y
L
Q
E
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.3
27.8
76.2
N.A.
72.5
71.8
N.A.
36.2
29
N.A.
47.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
46.3
44.6
86.1
N.A.
86.3
85.4
N.A.
54.4
47
N.A.
63.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
26.6
66.6
N.A.
53.3
66.6
N.A.
0
26.6
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
53.3
60
73.3
N.A.
80
86.6
N.A.
20
60
N.A.
60
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
12
12
0
0
23
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
12
0
0
0
0
0
0
12
0
0
% C
% Asp:
0
12
0
0
0
0
0
0
0
0
0
0
12
0
78
% D
% Glu:
0
34
34
0
0
0
0
0
0
0
12
0
12
34
12
% E
% Phe:
0
34
0
12
0
0
0
0
12
0
34
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
78
0
0
0
12
0
0
0
0
% I
% Lys:
0
0
0
0
12
0
0
0
0
0
0
0
12
0
0
% K
% Leu:
45
0
12
34
0
0
12
0
12
12
45
0
0
0
0
% L
% Met:
0
0
0
0
12
0
0
0
0
0
0
12
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
23
56
0
0
0
0
0
12
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
12
12
45
0
23
0
0
0
0
0
0
34
0
34
0
% Q
% Arg:
0
0
0
0
45
0
12
23
12
23
0
56
12
23
0
% R
% Ser:
0
12
12
0
0
56
0
23
0
23
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
12
12
0
0
0
45
0
0
% T
% Val:
0
0
0
45
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
45
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% W
% Tyr:
0
0
0
0
0
23
0
0
0
34
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _