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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TNKS All Species: 27.27
Human Site: T963 Identified Species: 50
UniProt: O95271 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95271 NP_003738.2 1327 142039 T963 M P P E A L P T C F K P Q A T
Chimpanzee Pan troglodytes XP_001137443 1327 142033 T963 M P P E A L P T C F K P Q A T
Rhesus Macaque Macaca mulatta XP_001090358 1327 142132 T963 M P P E A L P T C F K P Q A T
Dog Lupus familis XP_849388 1327 142003 T963 M P P E A L P T C F K P Q A T
Cat Felis silvestris
Mouse Mus musculus NP_780300 1320 140926 T956 M P P E A L P T C F K P Q A T
Rat Rattus norvegicus NP_001101077 1166 126761 G828 T A D A L S S G P S S P S S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508887 1320 142724 T956 M P P E A L P T C F K P Q A T
Chicken Gallus gallus Q5F478 990 107379 L652 G H T P C L R L L L E V A D N
Frog Xenopus laevis NP_001088420 1303 140252 S939 M P P E A L P S C F K P Q A T
Zebra Danio Brachydanio rerio Q502K3 1071 114412 A733 G R E D C L T A L L S H N V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651410 1181 127927 L842 S P T T E T V L L P T G A S M
Honey Bee Apis mellifera XP_396483 1166 127309 N828 N N G N N T I N S R P P S I V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001186587 1157 126547 P819 L P G P T T T P T T P S A S G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99.6 98.9 N.A. 96.5 72.2 N.A. 86.8 23.2 87.1 21.8 N.A. 59.4 62.7 N.A. 63.6
Protein Similarity: 100 99.6 99.7 99.1 N.A. 97 80.3 N.A. 89.1 37.4 90.9 37.3 N.A. 71.7 72.8 N.A. 74.6
P-Site Identity: 100 100 100 100 N.A. 100 6.6 N.A. 100 6.6 93.3 6.6 N.A. 6.6 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 100 13.3 100 20 N.A. 13.3 6.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 54 0 0 8 0 0 0 0 24 54 0 % A
% Cys: 0 0 0 0 16 0 0 0 54 0 0 0 0 0 0 % C
% Asp: 0 0 8 8 0 0 0 0 0 0 0 0 0 8 0 % D
% Glu: 0 0 8 54 8 0 0 0 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 54 0 0 0 0 0 % F
% Gly: 16 0 16 0 0 0 0 8 0 0 0 8 0 0 8 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 54 0 0 0 0 % K
% Leu: 8 0 0 0 8 70 0 16 24 16 0 0 0 0 8 % L
% Met: 54 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 8 8 0 8 8 0 0 8 0 0 0 0 8 0 8 % N
% Pro: 0 70 54 16 0 0 54 8 8 8 16 70 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 54 0 0 % Q
% Arg: 0 8 0 0 0 0 8 0 0 8 0 0 0 0 0 % R
% Ser: 8 0 0 0 0 8 8 8 8 8 16 8 16 24 8 % S
% Thr: 8 0 16 8 8 24 16 47 8 8 8 0 0 0 54 % T
% Val: 0 0 0 0 0 0 8 0 0 0 0 8 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _