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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VAPB All Species: 21.21
Human Site: S206 Identified Species: 42.42
UniProt: O95292 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95292 NP_004729.1 243 27228 S206 R K T V Q S N S P I S A L A P
Chimpanzee Pan troglodytes XP_001135371 233 26380 K195 R K V A H S D K P G S T S T A
Rhesus Macaque Macaca mulatta XP_001085676 243 27212 S206 R K T V Q S N S P I S A L A P
Dog Lupus familis XP_534466 243 27128 S206 R K T A Q S N S P V P V L A P
Cat Felis silvestris
Mouse Mus musculus Q9QY76 243 26928 S206 R K A M P S N S P V A A L A A
Rat Rattus norvegicus Q9Z269 243 26898 S206 R K A L P S N S P M A A L A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511021 243 27315 S206 R K P A Q S N S P I S A S A T
Chicken Gallus gallus NP_001006296 243 27255 N206 R K A P Q T N N P I S A S A A
Frog Xenopus laevis NP_001088528 243 27333 S206 R K M Q P T S S P H R P V S G
Zebra Danio Brachydanio rerio NP_997812 243 27387 A206 R K S T V M S A P H S S L A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785910 241 26909 Q204 Q R R V E G G Q P M K T V S P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40075 244 26907 A215 Q N Q I K E A A T V P A E N E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59.6 99.5 96.3 N.A. 89.7 88.4 N.A. 92.1 87.2 76.9 74.9 N.A. N.A. N.A. N.A. 48.1
Protein Similarity: 100 74 99.5 97.1 N.A. 94.6 94.2 N.A. 95.4 94.2 88.8 88 N.A. N.A. N.A. N.A. 67.4
P-Site Identity: 100 33.3 100 73.3 N.A. 60 60 N.A. 73.3 60 26.6 40 N.A. N.A. N.A. N.A. 20
P-Site Similarity: 100 40 100 80 N.A. 80 80 N.A. 73.3 73.3 53.3 66.6 N.A. N.A. N.A. N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 25 25 0 0 9 17 0 0 17 59 0 67 34 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 9 9 0 0 0 0 0 0 9 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 9 9 0 0 9 0 0 0 0 9 % G
% His: 0 0 0 0 9 0 0 0 0 17 0 0 0 0 0 % H
% Ile: 0 0 0 9 0 0 0 0 0 34 0 0 0 0 0 % I
% Lys: 0 84 0 0 9 0 0 9 0 0 9 0 0 0 0 % K
% Leu: 0 0 0 9 0 0 0 0 0 0 0 0 50 0 0 % L
% Met: 0 0 9 9 0 9 0 0 0 17 0 0 0 0 0 % M
% Asn: 0 9 0 0 0 0 59 9 0 0 0 0 0 9 0 % N
% Pro: 0 0 9 9 25 0 0 0 92 0 17 9 0 0 34 % P
% Gln: 17 0 9 9 42 0 0 9 0 0 0 0 0 0 0 % Q
% Arg: 84 9 9 0 0 0 0 0 0 0 9 0 0 0 0 % R
% Ser: 0 0 9 0 0 59 17 59 0 0 50 9 25 17 0 % S
% Thr: 0 0 25 9 0 17 0 0 9 0 0 17 0 9 9 % T
% Val: 0 0 9 25 9 0 0 0 0 25 0 9 17 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _