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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VAPB All Species: 17.88
Human Site: T214 Identified Species: 35.76
UniProt: O95292 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95292 NP_004729.1 243 27228 T214 P I S A L A P T G K E E G L S
Chimpanzee Pan troglodytes XP_001135371 233 26380 S203 P G S T S T A S F R D N V T S
Rhesus Macaque Macaca mulatta XP_001085676 243 27212 T214 P I S A L A P T G K E E G L S
Dog Lupus familis XP_534466 243 27128 A214 P V P V L A P A G K E E G L S
Cat Felis silvestris
Mouse Mus musculus Q9QY76 243 26928 T214 P V A A L A A T G K E E G L S
Rat Rattus norvegicus Q9Z269 243 26898 S214 P M A A L A A S G K E E G L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511021 243 27315 V214 P I S A S A T V V K E E G L S
Chicken Gallus gallus NP_001006296 243 27255 V214 P I S A S A A V V K D E G H S
Frog Xenopus laevis NP_001088528 243 27333 L214 P H R P V S G L A K E E G V N
Zebra Danio Brachydanio rerio NP_997812 243 27387 R214 P H S S L A V R V K E E G L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785910 241 26909 T212 P M K T V S P T V T E T K P M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40075 244 26907 S223 T V P A E N E S S S M G I F I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59.6 99.5 96.3 N.A. 89.7 88.4 N.A. 92.1 87.2 76.9 74.9 N.A. N.A. N.A. N.A. 48.1
Protein Similarity: 100 74 99.5 97.1 N.A. 94.6 94.2 N.A. 95.4 94.2 88.8 88 N.A. N.A. N.A. N.A. 67.4
P-Site Identity: 100 20 100 73.3 N.A. 80 73.3 N.A. 73.3 60 33.3 66.6 N.A. N.A. N.A. N.A. 26.6
P-Site Similarity: 100 40 100 80 N.A. 93.3 93.3 N.A. 73.3 66.6 60 73.3 N.A. N.A. N.A. N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 17 59 0 67 34 9 9 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 % D
% Glu: 0 0 0 0 9 0 9 0 0 0 75 75 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 9 0 0 0 0 9 0 % F
% Gly: 0 9 0 0 0 0 9 0 42 0 0 9 75 0 0 % G
% His: 0 17 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 34 0 0 0 0 0 0 0 0 0 0 9 0 9 % I
% Lys: 0 0 9 0 0 0 0 0 0 75 0 0 9 0 0 % K
% Leu: 0 0 0 0 50 0 0 9 0 0 0 0 0 59 0 % L
% Met: 0 17 0 0 0 0 0 0 0 0 9 0 0 0 9 % M
% Asn: 0 0 0 0 0 9 0 0 0 0 0 9 0 0 9 % N
% Pro: 92 0 17 9 0 0 34 0 0 0 0 0 0 9 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 9 0 0 0 0 9 0 9 0 0 0 0 0 % R
% Ser: 0 0 50 9 25 17 0 25 9 9 0 0 0 0 75 % S
% Thr: 9 0 0 17 0 9 9 34 0 9 0 9 0 9 0 % T
% Val: 0 25 0 9 17 0 9 17 34 0 0 0 9 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _