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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PGLS All Species: 46.67
Human Site: Y126 Identified Species: 68.44
UniProt: O95336 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95336 NP_036220.1 258 27547 Y126 V E E A A E D Y A K K L R Q A
Chimpanzee Pan troglodytes XP_001173626 258 27538 Y126 V E E A A E D Y A K K L R Q A
Rhesus Macaque Macaca mulatta XP_001113729 258 27825 Y126 V E E A A E D Y A K K L R Q V
Dog Lupus familis XP_852582 362 39074 Y230 V E E A A E D Y A K K L R Q A
Cat Felis silvestris
Mouse Mus musculus Q9CQ60 257 27236 Y126 V E D A A E D Y A R K L R Q A
Rat Rattus norvegicus P85971 257 27216 Y126 V E D A A E D Y A R K L R Q A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517951 261 27936 Y129 V E A A A A D Y A E K L R E A
Chicken Gallus gallus NP_001026759 250 26195 Y118 P N A A A A D Y A E R L R E A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VZ64 243 26653 D121 P L D A C A A D Y E A K V K S
Honey Bee Apis mellifera XP_624173 238 26246 Y115 A E D A A K D Y I K K M S V F
Nematode Worm Caenorhab. elegans O18229 269 30395 S131 T A Q H Y E I S L R K Y L L P
Sea Urchin Strong. purpuratus XP_791905 245 26412 Y117 V D E A A K D Y A E V V K K V
Poplar Tree Populus trichocarpa XP_002316080 266 29271 Y127 A E E A A D D Y E F H I R Q L
Maize Zea mays NP_001151429 281 31307 Y131 V E D A A T D Y E F M I R Q L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LMX8 268 29868 Y127 A E E A A T E Y E F A I R Q M
Baker's Yeast Sacchar. cerevisiae P38858 249 27766 N120 I G S D A E S N N K I A A E Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 85.6 68.7 N.A. 88.7 88.7 N.A. 79.3 69.3 N.A. N.A. N.A. 42.2 46.9 29.7 46.1
Protein Similarity: 100 99.6 89.5 70.4 N.A. 94.1 94.5 N.A. 85.4 78.2 N.A. N.A. N.A. 60 62 44.6 63.9
P-Site Identity: 100 100 93.3 100 N.A. 86.6 86.6 N.A. 73.3 53.3 N.A. N.A. N.A. 6.6 46.6 13.3 46.6
P-Site Similarity: 100 100 93.3 100 N.A. 100 100 N.A. 86.6 73.3 N.A. N.A. N.A. 33.3 66.6 26.6 86.6
Percent
Protein Identity: 41.3 37 N.A. 37.6 36 N.A.
Protein Similarity: 59.7 55.1 N.A. 55.9 51.5 N.A.
P-Site Identity: 53.3 53.3 N.A. 46.6 20 N.A.
P-Site Similarity: 66.6 66.6 N.A. 60 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 7 13 88 88 19 7 0 57 0 13 7 7 0 44 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 32 7 0 7 75 7 0 0 0 0 0 0 0 % D
% Glu: 0 69 44 0 0 50 7 0 19 25 0 0 0 19 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 19 0 0 0 0 7 % F
% Gly: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 7 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 7 0 7 0 7 19 0 0 0 % I
% Lys: 0 0 0 0 0 13 0 0 0 38 57 7 7 13 0 % K
% Leu: 0 7 0 0 0 0 0 0 7 0 0 50 7 7 13 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 7 0 0 7 % M
% Asn: 0 7 0 0 0 0 0 7 7 0 0 0 0 0 0 % N
% Pro: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 0 0 0 57 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 19 7 0 69 0 0 % R
% Ser: 0 0 7 0 0 0 7 7 0 0 0 0 7 0 7 % S
% Thr: 7 0 0 0 0 13 0 0 0 0 0 0 0 0 0 % T
% Val: 57 0 0 0 0 0 0 0 0 0 7 7 7 7 13 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 0 82 7 0 0 7 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _