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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB11
All Species:
6.06
Human Site:
S699
Identified Species:
12.12
UniProt:
O95342
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95342
NP_003733.2
1321
146407
S699
R
A
S
I
R
Q
R
S
K
S
Q
L
S
Y
L
Chimpanzee
Pan troglodytes
XP_526100
1321
146405
S699
R
A
S
I
R
Q
R
S
K
S
Q
L
S
Y
L
Rhesus Macaque
Macaca mulatta
XP_001097771
1223
135558
L656
V
Y
F
T
L
V
T
L
Q
S
Q
G
N
Q
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9QY30
1321
146658
Q699
S
L
R
A
S
I
R
Q
R
S
K
S
Q
L
S
Rat
Rattus norvegicus
O70127
1321
146240
Q699
S
L
R
A
S
I
R
Q
R
S
K
S
Q
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513897
1322
146482
R699
L
R
N
S
I
R
Q
R
S
Q
S
Q
L
S
N
Chicken
Gallus gallus
XP_418636
1307
144961
V702
T
R
K
S
I
K
R
V
R
I
Q
N
D
E
L
Frog
Xenopus laevis
NP_001081394
1287
141487
S681
S
S
R
N
T
I
K
S
K
V
P
E
T
E
D
Zebra Danio
Brachydanio rerio
XP_001923538
1297
143408
A659
S
Y
R
A
S
L
R
A
S
I
H
Q
R
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
N684
N
F
E
K
G
Q
K
N
S
V
Q
F
E
E
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
N695
S
E
M
D
D
I
M
N
R
V
R
S
S
T
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
L660
N
S
S
R
H
H
S
L
N
V
L
G
L
T
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89.1
N.A.
N.A.
81.9
82.4
N.A.
76.6
49.9
49.2
69.1
N.A.
38.5
N.A.
38.2
N.A.
Protein Similarity:
100
99.5
91.2
N.A.
N.A.
90.9
91.3
N.A.
88
68.5
68.1
81.9
N.A.
58.1
N.A.
58.2
N.A.
P-Site Identity:
100
100
13.3
N.A.
N.A.
13.3
13.3
N.A.
0
20
13.3
6.6
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
100
26.6
N.A.
N.A.
26.6
26.6
N.A.
20
33.3
33.3
13.3
N.A.
26.6
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
17
0
25
0
0
0
9
0
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
9
0
0
0
0
0
0
0
9
0
9
% D
% Glu:
0
9
9
0
0
0
0
0
0
0
0
9
9
25
0
% E
% Phe:
0
9
9
0
0
0
0
0
0
0
0
9
0
0
0
% F
% Gly:
0
0
0
0
9
0
0
0
0
0
0
17
0
0
0
% G
% His:
0
0
0
0
9
9
0
0
0
0
9
0
0
0
0
% H
% Ile:
0
0
0
17
17
34
0
0
0
17
0
0
0
0
9
% I
% Lys:
0
0
9
9
0
9
17
0
25
0
17
0
0
0
0
% K
% Leu:
9
17
0
0
9
9
0
17
0
0
9
17
17
17
25
% L
% Met:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
17
0
9
9
0
0
0
17
9
0
0
9
9
0
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
9
% P
% Gln:
0
0
0
0
0
25
9
17
9
9
42
17
17
9
0
% Q
% Arg:
17
17
34
9
17
9
50
9
34
0
9
0
9
0
9
% R
% Ser:
42
17
25
17
25
0
9
25
25
42
9
25
25
17
17
% S
% Thr:
9
0
0
9
9
0
9
0
0
0
0
0
9
17
9
% T
% Val:
9
0
0
0
0
9
0
9
0
34
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
17
0
0
0
0
0
0
0
0
0
0
0
17
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _