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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB11
All Species:
6.06
Human Site:
S719
Identified Species:
12.12
UniProt:
O95342
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95342
NP_003733.2
1321
146407
S719
L
A
V
V
D
H
K
S
T
Y
E
E
D
R
K
Chimpanzee
Pan troglodytes
XP_526100
1321
146405
S719
L
A
V
V
D
H
K
S
T
Y
E
E
D
R
K
Rhesus Macaque
Macaca mulatta
XP_001097771
1223
135558
D676
I
K
D
A
T
E
D
D
M
L
A
G
T
F
S
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9QY30
1321
146658
H719
P
P
L
A
I
G
D
H
K
S
S
Y
E
D
R
Rat
Rattus norvegicus
O70127
1321
146240
H719
P
P
L
A
V
A
D
H
K
S
S
Y
K
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513897
1322
146482
L719
P
F
A
V
M
E
M
L
N
P
F
E
E
D
R
Chicken
Gallus gallus
XP_418636
1307
144961
P722
Q
L
D
K
N
M
P
P
S
S
F
F
K
I
M
Frog
Xenopus laevis
NP_001081394
1287
141487
G701
E
E
K
K
K
E
E
G
P
P
P
V
S
F
F
Zebra Danio
Brachydanio rerio
XP_001923538
1297
143408
A679
A
V
P
E
S
S
V
A
I
A
G
E
L
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
S704
I
K
D
T
N
A
Q
S
A
E
A
P
P
E
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
E715
G
P
V
I
D
E
K
E
E
R
I
G
K
D
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
Q680
S
H
S
Q
R
A
G
Q
D
E
T
G
T
A
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89.1
N.A.
N.A.
81.9
82.4
N.A.
76.6
49.9
49.2
69.1
N.A.
38.5
N.A.
38.2
N.A.
Protein Similarity:
100
99.5
91.2
N.A.
N.A.
90.9
91.3
N.A.
88
68.5
68.1
81.9
N.A.
58.1
N.A.
58.2
N.A.
P-Site Identity:
100
100
0
N.A.
N.A.
0
0
N.A.
13.3
0
0
6.6
N.A.
13.3
N.A.
20
N.A.
P-Site Similarity:
100
100
6.6
N.A.
N.A.
20
6.6
N.A.
26.6
13.3
6.6
13.3
N.A.
33.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
17
9
25
0
25
0
9
9
9
17
0
0
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
25
0
25
0
25
9
9
0
0
0
17
34
0
% D
% Glu:
9
9
0
9
0
34
9
9
9
17
17
34
17
9
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
17
9
0
17
9
% F
% Gly:
9
0
0
0
0
9
9
9
0
0
9
25
0
9
0
% G
% His:
0
9
0
0
0
17
0
17
0
0
0
0
0
0
0
% H
% Ile:
17
0
0
9
9
0
0
0
9
0
9
0
0
9
0
% I
% Lys:
0
17
9
17
9
0
25
0
17
0
0
0
25
0
25
% K
% Leu:
17
9
17
0
0
0
0
9
0
9
0
0
9
0
0
% L
% Met:
0
0
0
0
9
9
9
0
9
0
0
0
0
0
9
% M
% Asn:
0
0
0
0
17
0
0
0
9
0
0
0
0
0
0
% N
% Pro:
25
25
9
0
0
0
9
9
9
17
9
9
9
0
9
% P
% Gln:
9
0
0
9
0
0
9
9
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
9
0
0
0
0
9
0
0
0
17
17
% R
% Ser:
9
0
9
0
9
9
0
25
9
25
17
0
9
0
25
% S
% Thr:
0
0
0
9
9
0
0
0
17
0
9
0
17
0
0
% T
% Val:
0
9
25
25
9
0
9
0
0
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
17
0
17
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _