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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB11
All Species:
6.97
Human Site:
T673
Identified Species:
13.94
UniProt:
O95342
Number Species:
11
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95342
NP_003733.2
1321
146407
T673
E
E
D
I
K
D
A
T
E
D
D
M
L
A
R
Chimpanzee
Pan troglodytes
XP_526100
1321
146405
T673
E
E
D
I
K
D
A
T
E
D
H
M
L
A
R
Rhesus Macaque
Macaca mulatta
XP_001097771
1223
135558
E630
A
D
T
I
I
G
F
E
H
G
A
A
V
E
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9QY30
1321
146658
D673
E
T
G
I
K
G
K
D
T
T
E
G
D
T
P
Rat
Rattus norvegicus
O70127
1321
146240
D673
E
T
S
I
M
G
K
D
A
T
E
G
G
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513897
1322
146482
L673
K
K
T
V
K
K
G
L
E
D
K
L
E
T
E
Chicken
Gallus gallus
XP_418636
1307
144961
S676
Q
E
E
G
N
A
S
S
V
S
E
E
A
L
N
Frog
Xenopus laevis
NP_001081394
1287
141487
I655
E
E
D
L
E
T
H
I
Y
E
K
K
I
P
V
Zebra Danio
Brachydanio rerio
XP_001923538
1297
143408
E633
Q
K
A
Q
Q
E
M
E
E
A
E
C
C
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
D658
E
K
E
D
S
I
E
D
T
K
Q
K
S
L
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
R669
A
A
E
G
K
F
S
R
E
N
S
V
A
R
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
S634
T
S
E
L
S
S
G
S
S
F
R
N
S
N
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89.1
N.A.
N.A.
81.9
82.4
N.A.
76.6
49.9
49.2
69.1
N.A.
38.5
N.A.
38.2
N.A.
Protein Similarity:
100
99.5
91.2
N.A.
N.A.
90.9
91.3
N.A.
88
68.5
68.1
81.9
N.A.
58.1
N.A.
58.2
N.A.
P-Site Identity:
100
93.3
13.3
N.A.
N.A.
20
13.3
N.A.
20
6.6
20
6.6
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
93.3
26.6
N.A.
N.A.
26.6
20
N.A.
46.6
40
46.6
40
N.A.
20
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
9
9
0
0
9
17
0
9
9
9
9
17
17
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
9
9
0
0
% C
% Asp:
0
9
25
9
0
17
0
25
0
25
9
0
9
9
0
% D
% Glu:
50
34
34
0
9
9
9
17
42
9
34
9
9
9
9
% E
% Phe:
0
0
0
0
0
9
9
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
9
17
0
25
17
0
0
9
0
17
9
0
0
% G
% His:
0
0
0
0
0
0
9
0
9
0
9
0
0
0
0
% H
% Ile:
0
0
0
42
9
9
0
9
0
0
0
0
9
0
0
% I
% Lys:
9
25
0
0
42
9
17
0
0
9
17
17
0
0
0
% K
% Leu:
0
0
0
17
0
0
0
9
0
0
0
9
17
17
17
% L
% Met:
0
0
0
0
9
0
9
0
0
0
0
17
0
0
0
% M
% Asn:
0
0
0
0
9
0
0
0
0
9
0
9
0
9
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
9
% P
% Gln:
17
0
0
9
9
0
0
0
0
0
9
0
0
0
9
% Q
% Arg:
0
0
0
0
0
0
0
9
0
0
9
0
0
9
25
% R
% Ser:
0
9
9
0
17
9
17
17
9
9
9
0
17
0
9
% S
% Thr:
9
17
17
0
0
9
0
17
17
17
0
0
0
25
0
% T
% Val:
0
0
0
9
0
0
0
0
9
0
0
9
9
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _