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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB11
All Species:
17.88
Human Site:
Y178
Identified Species:
35.76
UniProt:
O95342
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95342
NP_003733.2
1321
146407
Y178
I
Q
K
M
R
K
F
Y
F
R
R
I
M
R
M
Chimpanzee
Pan troglodytes
XP_526100
1321
146405
Y178
I
Q
K
M
R
K
F
Y
F
R
R
I
M
R
M
Rhesus Macaque
Macaca mulatta
XP_001097771
1223
135558
Q172
I
A
A
A
R
Q
T
Q
K
M
R
K
F
Y
F
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9QY30
1321
146658
Y178
I
R
K
M
R
K
F
Y
F
R
R
I
M
R
M
Rat
Rattus norvegicus
O70127
1321
146240
Y178
I
R
R
M
R
K
I
Y
F
R
R
I
M
R
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513897
1322
146482
Y178
I
Q
K
I
R
K
A
Y
F
R
N
V
M
R
M
Chicken
Gallus gallus
XP_418636
1307
144961
F182
I
K
R
I
R
Q
E
F
F
H
A
V
M
R
Q
Frog
Xenopus laevis
NP_001081394
1287
141487
F161
I
K
K
I
R
S
N
F
F
H
A
V
L
R
Q
Zebra Danio
Brachydanio rerio
XP_001923538
1297
143408
S158
I
G
W
F
D
C
T
S
V
G
E
L
N
T
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
D165
F
S
S
V
I
R
Q
D
I
G
W
H
D
L
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
F175
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
E159
D
V
E
T
N
T
G
E
V
V
G
R
M
S
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89.1
N.A.
N.A.
81.9
82.4
N.A.
76.6
49.9
49.2
69.1
N.A.
38.5
N.A.
38.2
N.A.
Protein Similarity:
100
99.5
91.2
N.A.
N.A.
90.9
91.3
N.A.
88
68.5
68.1
81.9
N.A.
58.1
N.A.
58.2
N.A.
P-Site Identity:
100
100
20
N.A.
N.A.
93.3
80
N.A.
73.3
33.3
33.3
6.6
N.A.
0
N.A.
20
N.A.
P-Site Similarity:
100
100
26.6
N.A.
N.A.
100
93.3
N.A.
86.6
73.3
66.6
13.3
N.A.
13.3
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
9
0
0
9
0
0
0
17
0
0
0
9
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
9
0
0
9
0
0
0
0
9
0
0
% D
% Glu:
0
0
9
0
0
0
17
9
0
0
9
0
0
0
0
% E
% Phe:
9
0
0
9
0
0
25
25
59
0
0
0
9
0
9
% F
% Gly:
0
9
0
0
0
0
9
0
0
17
9
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
17
0
9
0
0
0
% H
% Ile:
75
0
0
25
9
0
9
0
9
0
0
42
0
0
0
% I
% Lys:
0
17
42
0
0
42
0
0
9
9
0
9
0
0
0
% K
% Leu:
0
0
0
9
0
0
0
0
0
0
0
9
17
9
0
% L
% Met:
0
0
0
34
0
0
0
0
0
9
0
0
59
0
42
% M
% Asn:
9
9
0
0
9
0
9
0
0
0
9
0
9
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
25
0
0
0
17
9
9
0
0
0
0
0
0
25
% Q
% Arg:
0
17
25
0
75
17
0
0
0
42
42
9
0
67
9
% R
% Ser:
0
9
9
0
0
9
0
9
0
0
9
0
0
9
0
% S
% Thr:
0
0
0
9
0
9
17
0
0
0
0
0
0
9
0
% T
% Val:
0
9
0
9
0
0
0
0
25
9
0
25
0
0
0
% V
% Trp:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
42
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _