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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCB11
All Species:
7.88
Human Site:
Y705
Identified Species:
15.76
UniProt:
O95342
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95342
NP_003733.2
1321
146407
Y705
R
S
K
S
Q
L
S
Y
L
V
H
E
P
P
L
Chimpanzee
Pan troglodytes
XP_526100
1321
146405
Y705
R
S
K
S
Q
L
S
Y
L
V
H
E
P
P
L
Rhesus Macaque
Macaca mulatta
XP_001097771
1223
135558
Q662
T
L
Q
S
Q
G
N
Q
A
L
N
E
E
D
I
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9QY30
1321
146658
L705
R
Q
R
S
K
S
Q
L
S
H
L
S
H
E
P
Rat
Rattus norvegicus
O70127
1321
146240
L705
R
Q
R
S
K
S
Q
L
S
L
L
T
H
D
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513897
1322
146482
S705
Q
R
S
Q
S
Q
L
S
N
L
V
P
E
P
P
Chicken
Gallus gallus
XP_418636
1307
144961
E708
R
V
R
I
Q
N
D
E
L
D
V
K
A
D
Q
Frog
Xenopus laevis
NP_001081394
1287
141487
E687
K
S
K
V
P
E
T
E
D
K
E
V
D
E
E
Zebra Danio
Brachydanio rerio
XP_001923538
1297
143408
S665
R
A
S
I
H
Q
R
S
R
S
Q
L
S
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q00748
1302
143766
E690
K
N
S
V
Q
F
E
E
P
I
I
K
A
L
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34712
1321
145045
T701
M
N
R
V
R
S
S
T
I
G
S
I
T
N
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FWX7
1278
137648
T666
S
L
N
V
L
G
L
T
T
G
L
D
L
G
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89.1
N.A.
N.A.
81.9
82.4
N.A.
76.6
49.9
49.2
69.1
N.A.
38.5
N.A.
38.2
N.A.
Protein Similarity:
100
99.5
91.2
N.A.
N.A.
90.9
91.3
N.A.
88
68.5
68.1
81.9
N.A.
58.1
N.A.
58.2
N.A.
P-Site Identity:
100
100
20
N.A.
N.A.
13.3
13.3
N.A.
6.6
20
13.3
6.6
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
53.3
N.A.
N.A.
26.6
33.3
N.A.
20
33.3
26.6
13.3
N.A.
40
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
9
0
0
0
17
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
9
0
9
9
0
9
9
25
0
% D
% Glu:
0
0
0
0
0
9
9
25
0
0
9
25
17
17
9
% E
% Phe:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
17
0
0
0
17
0
0
0
9
9
% G
% His:
0
0
0
0
9
0
0
0
0
9
17
0
17
0
0
% H
% Ile:
0
0
0
17
0
0
0
0
9
9
9
9
0
0
17
% I
% Lys:
17
0
25
0
17
0
0
0
0
9
0
17
0
0
0
% K
% Leu:
0
17
0
0
9
17
17
17
25
25
25
9
9
9
17
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
17
9
0
0
9
9
0
9
0
9
0
0
17
0
% N
% Pro:
0
0
0
0
9
0
0
0
9
0
0
9
17
25
25
% P
% Gln:
9
17
9
9
42
17
17
9
0
0
9
0
0
0
9
% Q
% Arg:
50
9
34
0
9
0
9
0
9
0
0
0
0
0
0
% R
% Ser:
9
25
25
42
9
25
25
17
17
9
9
9
9
0
9
% S
% Thr:
9
0
0
0
0
0
9
17
9
0
0
9
9
0
0
% T
% Val:
0
9
0
34
0
0
0
0
0
17
17
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
17
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _