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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC2 All Species: 30.61
Human Site: S1122 Identified Species: 48.1
UniProt: O95347 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95347 NP_001036015.1 1197 135656 S1122 V D A A L D L S H T Q N I G Q
Chimpanzee Pan troglodytes XP_001137286 1197 135653 S1122 V D A A L D L S H T Q N I G Q
Rhesus Macaque Macaca mulatta XP_001110075 1197 135674 S1122 V D A A L D L S H T Q N I G Q
Dog Lupus familis XP_538759 1191 134851 L1121 E V D A A L D L S H T Q N I G
Cat Felis silvestris
Mouse Mus musculus Q8CG48 1191 134255 L1121 E V D A A L D L S H T Q N I G
Rat Rattus norvegicus P97690 1191 138430 S1121 Q L S G G Q K S L V A L A L I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90988 1189 134923 L1112 K P A P I Y I L D E V D A A L
Frog Xenopus laevis P50533 1203 136323 S1123 V D A A L D L S H T Q N I G Q
Zebra Danio Brachydanio rerio NP_955836 1199 135278 S1122 V D A A L D L S H T Q N I G Q
Tiger Blowfish Takifugu rubipres NP_001027796 1200 135717 S1122 V D A A L D L S H T Q N I G Q
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396284 1177 135689 P1106 L A M L L F K P A P L Y I L D
Nematode Worm Caenorhab. elegans Q09591 1244 140323 S1137 V D A A L D L S H T A N I G M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002304405 1176 132657 P1106 L L L F K P A P L Y I L D E V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SN90 1171 132296 S1091 Q R S L L A L S L I L A L L L
Baker's Yeast Sacchar. cerevisiae P38989 1170 133910 S1095 Q R S L I A L S L I M A L L Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99 95.4 N.A. 91.5 22.3 N.A. N.A. 66.8 80.7 74.4 71.1 N.A. 47.9 32.7 N.A.
Protein Similarity: 100 99.7 99.5 97.5 N.A. 95.1 46.7 N.A. N.A. 81.9 90.2 87.4 85.4 N.A. 70.2 54.2 N.A.
P-Site Identity: 100 100 100 6.6 N.A. 6.6 6.6 N.A. N.A. 6.6 100 100 100 N.A. 13.3 86.6 N.A.
P-Site Similarity: 100 100 100 6.6 N.A. 6.6 13.3 N.A. N.A. 26.6 100 100 100 N.A. 20 86.6 N.A.
Percent
Protein Identity: 44.9 N.A. N.A. 44.4 35.3 N.A.
Protein Similarity: 65.1 N.A. N.A. 64.1 58.2 N.A.
P-Site Identity: 0 N.A. N.A. 20 20 N.A.
P-Site Similarity: 6.6 N.A. N.A. 33.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 54 60 14 14 7 0 7 0 14 14 14 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 47 14 0 0 47 14 0 7 0 0 7 7 0 7 % D
% Glu: 14 0 0 0 0 0 0 0 0 7 0 0 0 7 0 % E
% Phe: 0 0 0 7 0 7 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 7 7 0 0 0 0 0 0 0 0 47 14 % G
% His: 0 0 0 0 0 0 0 0 47 14 0 0 0 0 0 % H
% Ile: 0 0 0 0 14 0 7 0 0 14 7 0 54 14 7 % I
% Lys: 7 0 0 0 7 0 14 0 0 0 0 0 0 0 0 % K
% Leu: 14 14 7 20 60 14 60 20 27 0 14 14 14 27 14 % L
% Met: 0 0 7 0 0 0 0 0 0 0 7 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 47 14 0 0 % N
% Pro: 0 7 0 7 0 7 0 14 0 7 0 0 0 0 0 % P
% Gln: 20 0 0 0 0 7 0 0 0 0 40 14 0 0 47 % Q
% Arg: 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 20 0 0 0 0 67 14 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 47 14 0 0 0 0 % T
% Val: 47 14 0 0 0 0 0 0 0 7 7 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 0 0 0 7 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _