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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC2
All Species:
37.58
Human Site:
S249
Identified Species:
59.05
UniProt:
O95347
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95347
NP_001036015.1
1197
135656
S249
A
E
D
T
K
V
R
S
A
E
E
L
K
E
M
Chimpanzee
Pan troglodytes
XP_001137286
1197
135653
S249
A
E
D
T
K
V
R
S
A
E
E
L
K
E
M
Rhesus Macaque
Macaca mulatta
XP_001110075
1197
135674
S249
A
E
D
T
K
A
R
S
A
E
E
L
K
E
M
Dog
Lupus familis
XP_538759
1191
134851
S249
A
E
D
T
K
E
R
S
A
E
E
L
K
E
M
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG48
1191
134255
S249
A
E
D
T
K
E
R
S
A
G
E
L
K
E
M
Rat
Rattus norvegicus
P97690
1191
138430
R246
L
D
E
L
S
A
K
R
E
T
S
G
E
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90988
1189
134923
S249
A
E
E
I
K
D
R
S
T
N
A
L
K
E
A
Frog
Xenopus laevis
P50533
1203
136323
S249
A
E
E
T
K
V
R
S
A
E
E
L
K
E
M
Zebra Danio
Brachydanio rerio
NP_955836
1199
135278
S249
A
E
E
T
K
L
K
S
N
E
E
L
Q
E
M
Tiger Blowfish
Takifugu rubipres
NP_001027796
1200
135717
S249
A
E
E
T
K
L
K
S
A
D
N
L
K
V
M
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396284
1177
135689
A249
A
L
N
E
S
Q
N
A
E
E
N
A
Q
I
V
Nematode Worm
Caenorhab. elegans
Q09591
1244
140323
S250
T
C
E
A
V
K
K
S
A
K
E
I
E
D
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002304405
1176
132657
A249
A
V
K
I
R
D
S
A
V
V
E
V
E
H
M
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SN90
1171
132296
S249
A
E
K
I
R
D
N
S
I
H
V
V
E
E
M
Baker's Yeast
Sacchar. cerevisiae
P38989
1170
133910
I249
I
K
H
K
H
T
S
I
R
E
T
L
E
N
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
95.4
N.A.
91.5
22.3
N.A.
N.A.
66.8
80.7
74.4
71.1
N.A.
47.9
32.7
N.A.
Protein Similarity:
100
99.7
99.5
97.5
N.A.
95.1
46.7
N.A.
N.A.
81.9
90.2
87.4
85.4
N.A.
70.2
54.2
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
86.6
0
N.A.
N.A.
53.3
93.3
66.6
60
N.A.
13.3
20
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
86.6
33.3
N.A.
N.A.
60
100
93.3
86.6
N.A.
40
60
N.A.
Percent
Protein Identity:
44.9
N.A.
N.A.
44.4
35.3
N.A.
Protein Similarity:
65.1
N.A.
N.A.
64.1
58.2
N.A.
P-Site Identity:
20
N.A.
N.A.
33.3
13.3
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
53.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
80
0
0
7
0
14
0
14
54
0
7
7
0
0
14
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
34
0
0
20
0
0
0
7
0
0
0
7
0
% D
% Glu:
0
67
40
7
0
14
0
0
14
54
60
0
34
60
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
7
% G
% His:
0
0
7
0
7
0
0
0
0
7
0
0
0
7
0
% H
% Ile:
7
0
0
20
0
0
0
7
7
0
0
7
0
7
0
% I
% Lys:
0
7
14
7
60
7
27
0
0
7
0
0
54
7
0
% K
% Leu:
7
7
0
7
0
14
0
0
0
0
0
67
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
67
% M
% Asn:
0
0
7
0
0
0
14
0
7
7
14
0
0
7
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
0
0
14
0
0
% Q
% Arg:
0
0
0
0
14
0
47
7
7
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
14
0
14
74
0
0
7
0
0
0
7
% S
% Thr:
7
0
0
54
0
7
0
0
7
7
7
0
0
0
0
% T
% Val:
0
7
0
0
7
20
0
0
7
7
7
14
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _