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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC2 All Species: 19.09
Human Site: S342 Identified Species: 30
UniProt: O95347 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95347 NP_001036015.1 1197 135656 S342 E K N M V E D S K T L A A K E
Chimpanzee Pan troglodytes XP_001137286 1197 135653 S342 E K N M V E D S K T L A A K E
Rhesus Macaque Macaca mulatta XP_001110075 1197 135674 S342 E K N M I E D S K T L A A K E
Dog Lupus familis XP_538759 1191 134851 S342 E K N M I E D S R T L A A K E
Cat Felis silvestris
Mouse Mus musculus Q8CG48 1191 134255 S342 Q N S M A E D S K A L A A K E
Rat Rattus norvegicus P97690 1191 138430 R330 R K R L L K E R Q K L L E K I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90988 1189 134923 F342 I K I M Q E E F K A F T S K E
Frog Xenopus laevis P50533 1203 136323 D342 L V K S M E E D A K V L T A K
Zebra Danio Brachydanio rerio NP_955836 1199 135278 K342 V K N M E E D K K V M S A K E
Tiger Blowfish Takifugu rubipres NP_001027796 1200 135717 K342 V K N M E E D K K M L I V K E
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396284 1177 135689 E342 K I N I A D D E N I F V A K Q
Nematode Worm Caenorhab. elegans Q09591 1244 140323 R341 N K S L S K D R E V L D A K R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002304405 1176 132657 K342 V H S I E D L K Q S V E E R A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SN90 1171 132296 K342 V H N I E D L K K S V E E R A
Baker's Yeast Sacchar. cerevisiae P38989 1170 133910 S344 E S E I A S S S A K L I E K K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 99 95.4 N.A. 91.5 22.3 N.A. N.A. 66.8 80.7 74.4 71.1 N.A. 47.9 32.7 N.A.
Protein Similarity: 100 99.7 99.5 97.5 N.A. 95.1 46.7 N.A. N.A. 81.9 90.2 87.4 85.4 N.A. 70.2 54.2 N.A.
P-Site Identity: 100 100 93.3 86.6 N.A. 66.6 20 N.A. N.A. 40 6.6 60 60 N.A. 26.6 33.3 N.A.
P-Site Similarity: 100 100 100 100 N.A. 80 53.3 N.A. N.A. 53.3 33.3 73.3 60 N.A. 53.3 60 N.A.
Percent
Protein Identity: 44.9 N.A. N.A. 44.4 35.3 N.A.
Protein Similarity: 65.1 N.A. N.A. 64.1 58.2 N.A.
P-Site Identity: 0 N.A. N.A. 13.3 26.6 N.A.
P-Site Similarity: 46.6 N.A. N.A. 46.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 20 0 0 0 14 14 0 34 54 7 14 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 20 60 7 0 0 0 7 0 0 0 % D
% Glu: 34 0 7 0 27 60 20 7 7 0 0 14 27 0 54 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 14 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 7 7 27 14 0 0 0 0 7 0 14 0 0 7 % I
% Lys: 7 60 7 0 0 14 0 27 54 20 0 0 0 80 14 % K
% Leu: 7 0 0 14 7 0 14 0 0 0 60 14 0 0 0 % L
% Met: 0 0 0 54 7 0 0 0 0 7 7 0 0 0 0 % M
% Asn: 7 7 54 0 0 0 0 0 7 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 0 0 0 7 0 0 0 14 0 0 0 0 0 7 % Q
% Arg: 7 0 7 0 0 0 0 14 7 0 0 0 0 14 7 % R
% Ser: 0 7 20 7 7 7 7 40 0 14 0 7 7 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 27 0 7 7 0 0 % T
% Val: 27 7 0 0 14 0 0 0 0 14 20 7 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _