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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC2
All Species:
39.7
Human Site:
T647
Identified Species:
62.38
UniProt:
O95347
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95347
NP_001036015.1
1197
135656
T647
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
Chimpanzee
Pan troglodytes
XP_001137286
1197
135653
T647
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
Rhesus Macaque
Macaca mulatta
XP_001110075
1197
135674
T647
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
Dog
Lupus familis
XP_538759
1191
134851
T647
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG48
1191
134255
T647
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
Rat
Rattus norvegicus
P97690
1191
138430
M648
Q
L
A
R
A
F
T
M
D
C
I
T
L
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90988
1189
134923
R647
T
F
D
K
R
I
M
R
K
T
V
T
L
Q
G
Frog
Xenopus laevis
P50533
1203
136323
T648
T
F
D
K
R
I
M
T
K
T
V
T
L
G
G
Zebra Danio
Brachydanio rerio
NP_955836
1199
135278
T647
A
F
D
K
G
V
S
T
K
T
V
T
L
G
G
Tiger Blowfish
Takifugu rubipres
NP_001027796
1200
135717
T647
A
F
D
K
H
V
M
T
K
T
V
T
L
G
G
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396284
1177
135689
K647
A
F
H
D
N
I
M
K
K
C
V
T
L
E
G
Nematode Worm
Caenorhab. elegans
Q09591
1244
140323
T661
A
Y
D
E
V
A
K
T
R
M
I
T
R
R
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002304405
1176
132657
T645
A
F
S
R
E
I
R
T
P
S
V
T
L
E
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SN90
1171
132296
T642
A
F
N
R
E
I
R
T
P
S
V
T
L
E
G
Baker's Yeast
Sacchar. cerevisiae
P38989
1170
133910
A649
T
F
H
P
K
I
R
A
R
S
I
T
L
Q
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
95.4
N.A.
91.5
22.3
N.A.
N.A.
66.8
80.7
74.4
71.1
N.A.
47.9
32.7
N.A.
Protein Similarity:
100
99.7
99.5
97.5
N.A.
95.1
46.7
N.A.
N.A.
81.9
90.2
87.4
85.4
N.A.
70.2
54.2
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
20
N.A.
N.A.
73.3
86.6
73.3
80
N.A.
53.3
40
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
N.A.
80
93.3
86.6
93.3
N.A.
60
60
N.A.
Percent
Protein Identity:
44.9
N.A.
N.A.
44.4
35.3
N.A.
Protein Similarity:
65.1
N.A.
N.A.
64.1
58.2
N.A.
P-Site Identity:
53.3
N.A.
N.A.
53.3
40
N.A.
P-Site Similarity:
66.6
N.A.
N.A.
73.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
74
0
7
0
7
7
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
14
0
0
0
0
0
% C
% Asp:
0
0
67
7
0
0
0
0
7
0
0
0
0
0
0
% D
% Glu:
0
0
0
7
14
0
0
0
0
0
0
0
0
27
0
% E
% Phe:
0
87
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
0
0
54
100
% G
% His:
0
0
14
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
74
0
0
0
0
20
0
0
0
0
% I
% Lys:
0
0
0
60
7
0
7
7
34
0
0
0
0
0
0
% K
% Leu:
0
7
0
0
0
0
0
0
0
0
0
0
94
0
0
% L
% Met:
0
0
0
0
0
0
60
7
0
7
0
0
0
0
0
% M
% Asn:
0
0
7
0
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
7
0
0
0
0
14
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% Q
% Arg:
0
0
0
20
47
0
20
7
47
0
0
0
7
7
0
% R
% Ser:
0
0
7
0
0
0
7
0
0
20
0
0
0
0
0
% S
% Thr:
20
0
0
0
0
0
7
74
0
60
0
100
0
0
0
% T
% Val:
0
0
0
0
7
14
0
0
0
0
80
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _