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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC2
All Species:
44.85
Human Site:
Y217
Identified Species:
70.48
UniProt:
O95347
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95347
NP_001036015.1
1197
135656
Y217
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
V
M
Chimpanzee
Pan troglodytes
XP_001137286
1197
135653
Y217
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
V
M
Rhesus Macaque
Macaca mulatta
XP_001110075
1197
135674
Y217
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
V
M
Dog
Lupus familis
XP_538759
1191
134851
Y217
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
I
M
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG48
1191
134255
Y217
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
V
M
Rat
Rattus norvegicus
P97690
1191
138430
Q214
K
E
E
L
A
Q
Y
Q
K
W
D
K
M
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90988
1189
134923
Y217
L
K
E
A
R
A
S
Y
L
E
Y
Q
K
M
T
Frog
Xenopus laevis
P50533
1203
136323
Y217
L
K
E
E
R
S
S
Y
L
E
Y
Q
K
I
M
Zebra Danio
Brachydanio rerio
NP_955836
1199
135278
Y217
L
K
E
E
R
A
S
Y
L
E
Y
Q
K
L
M
Tiger Blowfish
Takifugu rubipres
NP_001027796
1200
135717
Y217
L
Q
E
E
R
S
S
Y
L
E
Y
Q
K
L
M
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396284
1177
135689
Y217
L
K
E
E
K
I
Q
Y
V
E
F
Q
R
I
E
Nematode Worm
Caenorhab. elegans
Q09591
1244
140323
M218
F
R
E
D
R
K
N
M
V
E
V
T
R
L
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002304405
1176
132657
Y217
L
R
K
E
R
M
Q
Y
M
Q
W
A
N
G
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SN90
1171
132296
Y217
L
R
R
E
K
S
Q
Y
M
Q
W
A
N
G
N
Baker's Yeast
Sacchar. cerevisiae
P38989
1170
133910
F217
L
R
N
E
K
R
M
F
L
E
F
Q
S
T
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99
95.4
N.A.
91.5
22.3
N.A.
N.A.
66.8
80.7
74.4
71.1
N.A.
47.9
32.7
N.A.
Protein Similarity:
100
99.7
99.5
97.5
N.A.
95.1
46.7
N.A.
N.A.
81.9
90.2
87.4
85.4
N.A.
70.2
54.2
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
100
6.6
N.A.
N.A.
73.3
93.3
86.6
86.6
N.A.
46.6
20
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
N.A.
86.6
100
100
100
N.A.
80
60
N.A.
Percent
Protein Identity:
44.9
N.A.
N.A.
44.4
35.3
N.A.
Protein Similarity:
65.1
N.A.
N.A.
64.1
58.2
N.A.
P-Site Identity:
26.6
N.A.
N.A.
26.6
33.3
N.A.
P-Site Similarity:
60
N.A.
N.A.
60
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
14
0
0
0
0
0
14
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
0
0
0
0
7
0
0
0
0
% D
% Glu:
0
7
80
80
0
0
0
0
0
80
0
0
0
0
7
% E
% Phe:
7
0
0
0
0
0
0
7
0
0
14
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
0
0
0
0
0
20
0
% I
% Lys:
7
60
7
0
20
7
0
0
7
0
0
7
60
0
7
% K
% Leu:
87
0
0
7
0
0
0
0
67
0
0
0
0
20
0
% L
% Met:
0
0
0
0
0
7
7
7
14
0
0
0
7
7
54
% M
% Asn:
0
0
7
0
0
0
7
0
0
0
0
0
14
0
14
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
7
0
0
0
7
20
7
0
14
0
74
0
0
7
% Q
% Arg:
0
27
7
0
74
7
0
0
0
0
0
0
14
7
7
% R
% Ser:
0
0
0
0
0
54
60
0
0
0
0
0
7
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
7
% T
% Val:
0
0
0
0
0
0
0
0
14
0
7
0
0
27
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
14
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
80
0
0
60
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _