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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RAPGEF3
All Species:
21.82
Human Site:
Y562
Identified Species:
43.64
UniProt:
O95398
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95398
NP_001092001.1
923
103652
Y562
Q
V
G
D
K
V
P
Y
D
I
C
R
P
D
H
Chimpanzee
Pan troglodytes
XP_522596
881
99309
Y520
R
V
G
D
K
V
P
Y
D
I
C
R
P
D
H
Rhesus Macaque
Macaca mulatta
XP_001098291
908
101616
Y562
R
V
G
D
K
V
P
Y
D
I
C
L
P
D
H
Dog
Lupus familis
XP_861033
858
98130
F519
R
G
S
D
E
V
L
F
K
V
Y
C
M
D
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCC8
918
103514
Y565
R
V
G
D
K
V
P
Y
D
I
C
R
P
D
H
Rat
Rattus norvegicus
Q9Z1C8
926
104540
Y565
R
V
G
D
K
V
P
Y
D
I
C
R
P
D
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514742
1011
115505
F672
R
G
S
D
E
I
L
F
K
V
Y
C
I
D
H
Chicken
Gallus gallus
XP_426579
1011
115518
F672
R
G
S
D
E
V
L
F
K
V
Y
C
I
D
Q
Frog
Xenopus laevis
NP_001089076
890
102453
Y525
R
A
G
D
K
V
P
Y
D
I
Y
R
P
D
H
Zebra Danio
Brachydanio rerio
XP_002662318
1005
114531
L666
R
S
F
D
D
I
L
L
K
V
Y
C
S
D
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_724498
861
97407
F519
R
P
D
D
D
I
I
F
R
V
Y
C
A
D
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34578
1234
141798
Q889
L
P
S
D
V
C
N
Q
I
I
Y
L
A
D
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.2
94.1
48.3
N.A.
89.8
90.2
N.A.
44.6
44.5
57.3
44.3
N.A.
39.5
N.A.
27.2
N.A.
Protein Similarity:
100
95.3
95.1
66.1
N.A.
93.5
94.1
N.A.
63.4
62.2
73.5
60.7
N.A.
56.6
N.A.
42.2
N.A.
P-Site Identity:
100
93.3
86.6
26.6
N.A.
93.3
93.3
N.A.
20
20
80
20
N.A.
20
N.A.
20
N.A.
P-Site Similarity:
100
100
93.3
53.3
N.A.
100
100
N.A.
53.3
46.6
86.6
40
N.A.
46.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
0
0
0
17
0
0
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
42
42
0
0
0
% C
% Asp:
0
0
9
100
17
0
0
0
50
0
0
0
0
100
0
% D
% Glu:
0
0
0
0
25
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
9
0
0
0
0
34
0
0
0
0
0
0
0
% F
% Gly:
0
25
50
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
84
% H
% Ile:
0
0
0
0
0
25
9
0
9
59
0
0
17
0
0
% I
% Lys:
0
0
0
0
50
0
0
0
34
0
0
0
0
0
0
% K
% Leu:
9
0
0
0
0
0
34
9
0
0
0
17
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
17
0
0
0
0
50
0
0
0
0
0
50
0
0
% P
% Gln:
9
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% Q
% Arg:
84
0
0
0
0
0
0
0
9
0
0
42
0
0
0
% R
% Ser:
0
9
34
0
0
0
0
0
0
0
0
0
9
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% T
% Val:
0
42
0
0
9
67
0
0
0
42
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
59
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _