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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PIGN All Species: 29.7
Human Site: S277 Identified Species: 59.39
UniProt: O95427 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95427 NP_036459.1 931 105810 S277 S H G A G H P S E T L T P L V
Chimpanzee Pan troglodytes XP_512161 931 105786 S277 S H G A G H P S E T L T P L V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533387 987 112230 S333 F H G A G H P S E T L T P F V
Cat Felis silvestris
Mouse Mus musculus Q9R1S3 931 105027 S277 S H G A G H P S E T L T P F V
Rat Rattus norvegicus NP_001094054 931 104957 S277 S H G A G H P S E T L T P F V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505836 960 108183 S305 S H G A G H P S E T L T P L I
Chicken Gallus gallus XP_418994 933 104963 S279 S H G A G H P S E T L T P L I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001121709 662 74613 G53 L V L F V A D G L R A D S L F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001192083 529 59421
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_186787 993 112037 T316 S H G D G H P T N T D T P L V
Baker's Yeast Sacchar. cerevisiae P36051 919 105675 N286 S H G D G H P N N T R T P L V
Red Bread Mold Neurospora crassa Q7SAP1 996 110539 D294 S H G D G H P D N T R T P L I
Conservation
Percent
Protein Identity: 100 99.3 N.A. 80.9 N.A. 87.3 87.2 N.A. 72.8 71.4 N.A. 44.4 N.A. N.A. N.A. N.A. 35.3
Protein Similarity: 100 99.4 N.A. 86.3 N.A. 92.3 93.2 N.A. 84 83.8 N.A. 58.1 N.A. N.A. N.A. N.A. 44.4
P-Site Identity: 100 100 N.A. 86.6 N.A. 93.3 93.3 N.A. 93.3 93.3 N.A. 6.6 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 N.A. 86.6 N.A. 93.3 93.3 N.A. 100 100 N.A. 6.6 N.A. N.A. N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. 37.6 38.5 40.3
Protein Similarity: N.A. N.A. N.A. 56.7 59.5 57.2
P-Site Identity: N.A. N.A. N.A. 73.3 73.3 66.6
P-Site Similarity: N.A. N.A. N.A. 80 80 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 59 0 9 0 0 0 0 9 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 25 0 0 9 9 0 0 9 9 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 59 0 0 0 0 0 0 % E
% Phe: 9 0 0 9 0 0 0 0 0 0 0 0 0 25 9 % F
% Gly: 0 0 84 0 84 0 0 9 0 0 0 0 0 0 0 % G
% His: 0 84 0 0 0 84 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 0 9 0 0 0 0 0 9 0 59 0 0 67 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 9 25 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 84 0 0 0 0 0 84 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 9 17 0 0 0 0 % R
% Ser: 75 0 0 0 0 0 0 59 0 0 0 0 9 0 0 % S
% Thr: 0 0 0 0 0 0 0 9 0 84 0 84 0 0 0 % T
% Val: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 59 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _