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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TGDS All Species: 32.73
Human Site: S141 Identified Species: 60
UniProt: O95455 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95455 NP_055120.1 350 40214 S141 V E K F I Y V S T D E V Y G G
Chimpanzee Pan troglodytes XP_522697 350 40132 S141 V E K F I Y V S T D E V Y G G
Rhesus Macaque Macaca mulatta XP_001083495 350 40133 S141 V E K F I Y V S T D E V Y G G
Dog Lupus familis XP_542640 514 57720 S300 V E K F I Y V S T D E V Y G G
Cat Felis silvestris
Mouse Mus musculus Q8VDR7 355 40580 S141 V E K F I Y V S T D E V Y G G
Rat Rattus norvegicus Q5PQX0 420 47520 Y206 L A S T S E V Y G D P E V H P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512139 406 46234 S191 V E K F I Y V S T D E V Y G G
Chicken Gallus gallus XP_416988 357 41177 S138 V E K F V Y V S T D E V Y G G
Frog Xenopus laevis NP_001088301 351 40134 S140 V E K F V Y I S T D E V Y G G
Zebra Danio Brachydanio rerio NP_956111 274 30744 V83 F S T E H I D V V F H C A A E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002330754 660 74671 E138 F I H V S T D E V Y G E T D M
Maize Zea mays NP_001130297 676 76169 V141 Q I K R F I H V S T D E V Y G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SYM5 669 75353 D293 N D Q R Y F L D D Q K L K K L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 98.8 65.7 N.A. 89.5 22.1 N.A. 78.3 83.1 72.9 49.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.1 99.1 67.1 N.A. 94 39.2 N.A. 83.2 90.1 87.4 61.1 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. 100 93.3 86.6 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 100 100 100 0 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: 26.5 25 N.A. 24.9 N.A. N.A.
Protein Similarity: 38 35.9 N.A. 35.8 N.A. N.A.
P-Site Identity: 0 13.3 N.A. 0 N.A. N.A.
P-Site Similarity: 0 26.6 N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 0 0 0 0 0 0 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 8 0 0 0 0 16 8 8 70 8 0 0 8 0 % D
% Glu: 0 62 0 8 0 8 0 8 0 0 62 24 0 0 8 % E
% Phe: 16 0 0 62 8 8 0 0 0 8 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 8 0 8 0 0 62 70 % G
% His: 0 0 8 0 8 0 8 0 0 0 8 0 0 8 0 % H
% Ile: 0 16 0 0 47 16 8 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 70 0 0 0 0 0 0 0 8 0 8 8 0 % K
% Leu: 8 0 0 0 0 0 8 0 0 0 0 8 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 8 % P
% Gln: 8 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 0 0 16 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 8 8 0 16 0 0 62 8 0 0 0 0 0 0 % S
% Thr: 0 0 8 8 0 8 0 0 62 8 0 0 8 0 0 % T
% Val: 62 0 0 8 16 0 62 16 16 0 0 62 16 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 62 0 8 0 8 0 0 62 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _