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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LARGE All Species: 31.52
Human Site: S609 Identified Species: 63.03
UniProt: O95461 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95461 NP_004728.1 756 88066 S609 Y R L S F P K S K A E L L S M
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001112944 756 88032 S609 Y R L S F P K S K A E L L S M
Dog Lupus familis XP_531751 827 95704 S680 Y R L S F P K S K A E L L S M
Cat Felis silvestris
Mouse Mus musculus Q9Z1M7 756 87945 S609 Y R L S F P K S K A E L L S M
Rat Rattus norvegicus Q6P7A1 690 79291 L552 T L L D A G S L H T F R Y H E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510588 766 89047 S619 Y R L S F P K S K A E L L S M
Chicken Gallus gallus Q66PG3 756 88027 S609 Y R L S F P K S K A E L L S M
Frog Xenopus laevis Q6PA90 723 83130 S576 Y R L S F P K S K A D L L S M
Zebra Danio Brachydanio rerio Q66PG2 757 87655 S610 Y R L S F P K S K A E L L S Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624139 712 83352 R571 R G V L Y T F R Y H V W T Q G
Nematode Worm Caenorhab. elegans Q21389 631 74506 K493 L S N F L S R K D L V I E H L
Sea Urchin Strong. purpuratus XP_781563 562 65956 M424 S K A D L L H M L D M G T L F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.8 88.7 N.A. 97.7 60 N.A. 91.7 95.9 71.1 84.6 N.A. N.A. 46.1 28.9 56.3
Protein Similarity: 100 N.A. 100 90.3 N.A. 99.2 74.5 N.A. 94.5 98.4 81.6 91.9 N.A. N.A. 63 46.4 64.8
P-Site Identity: 100 N.A. 100 100 N.A. 100 6.6 N.A. 100 100 93.3 93.3 N.A. N.A. 0 0 0
P-Site Similarity: 100 N.A. 100 100 N.A. 100 6.6 N.A. 100 100 100 93.3 N.A. N.A. 13.3 20 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 9 0 0 0 0 67 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 17 0 0 0 0 9 9 9 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 59 0 9 0 9 % E
% Phe: 0 0 0 9 67 0 9 0 0 0 9 0 0 0 9 % F
% Gly: 0 9 0 0 0 9 0 0 0 0 0 9 0 0 9 % G
% His: 0 0 0 0 0 0 9 0 9 9 0 0 0 17 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % I
% Lys: 0 9 0 0 0 0 67 9 67 0 0 0 0 0 0 % K
% Leu: 9 9 75 9 17 9 0 9 9 9 0 67 67 9 9 % L
% Met: 0 0 0 0 0 0 0 9 0 0 9 0 0 0 59 % M
% Asn: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 67 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 % Q
% Arg: 9 67 0 0 0 0 9 9 0 0 0 9 0 0 0 % R
% Ser: 9 9 0 67 0 9 9 67 0 0 0 0 0 67 0 % S
% Thr: 9 0 0 0 0 9 0 0 0 9 0 0 17 0 0 % T
% Val: 0 0 9 0 0 0 0 0 0 0 17 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 67 0 0 0 9 0 0 0 9 0 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _