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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SGPL1 All Species: 44.24
Human Site: S395 Identified Species: 60.83
UniProt: O95470 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95470 NP_003892.2 568 63524 S395 A S P T I A G S R P G G I S A
Chimpanzee Pan troglodytes XP_521504 568 63517 S395 A S P T I A G S R P G G I S A
Rhesus Macaque Macaca mulatta XP_001106861 633 70448 S460 A S P T I A G S R P G G I S A
Dog Lupus familis XP_546150 568 63418 S395 A S P T I A G S R P G G I S A
Cat Felis silvestris
Mouse Mus musculus Q8R0X7 568 63659 S395 A S P S I A G S R P G G I I A
Rat Rattus norvegicus Q8CHN6 568 63740 S395 A S P S I A G S R P G G I I A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508856 560 61966 S387 A S P T I A G S R P G G I I A
Chicken Gallus gallus NP_001007947 561 62425 S388 A S P S I A G S R A G G I I A
Frog Xenopus laevis NP_001091225 453 50814 S285 K A M K R A I S K N T A M L V
Zebra Danio Brachydanio rerio NP_001082938 572 63710 S391 A S P S M A G S R P G G I I A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V7Y2 545 60287 S378 W P G G V Y G S P T V N G S R
Honey Bee Apis mellifera XP_623988 549 61593 S380 G S P T V S G S R A G G V I A
Nematode Worm Caenorhab. elegans Q9Y194 552 61079 P384 C G G I Y A T P T I A G S R A
Sea Urchin Strong. purpuratus XP_790556 422 46078 P256 T G G I Y A T P T I G G S R A
Poplar Tree Populus trichocarpa XP_002304674 540 58782 W374 Q F V A V T E W S G G L Y V S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9C509 544 59459 W378 Q F V A V T E W S G G L Y V S
Baker's Yeast Sacchar. cerevisiae Q05567 589 65547 S422 G S P T L A G S R P G A I V V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 89.2 93.3 N.A. 84.6 85.5 N.A. 77.2 68.4 51.4 63.4 N.A. 46.4 48.2 41 44.3
Protein Similarity: 100 99.8 89.5 96.6 N.A. 92 91.7 N.A. 85.9 81.3 63.3 79.7 N.A. 64.7 66.5 58.7 57.9
P-Site Identity: 100 100 100 100 N.A. 86.6 86.6 N.A. 93.3 80 13.3 80 N.A. 20 60 20 26.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3 86.6 33.3 93.3 N.A. 26.6 80 20 26.6
Percent
Protein Identity: 41.9 N.A. N.A. 40.6 37 N.A.
Protein Similarity: 58.9 N.A. N.A. 59.1 57 N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 66.6 N.A.
P-Site Similarity: 20 N.A. N.A. 20 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 53 6 0 12 0 77 0 0 0 12 6 12 0 0 71 % A
% Cys: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % E
% Phe: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 12 12 18 6 0 0 71 0 0 12 83 71 6 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 12 48 0 6 0 0 12 0 0 59 36 0 % I
% Lys: 6 0 0 6 0 0 0 0 6 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 6 0 0 0 0 0 0 12 0 6 0 % L
% Met: 0 0 6 0 6 0 0 0 0 0 0 0 6 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 6 0 6 0 0 0 % N
% Pro: 0 6 65 0 0 0 0 12 6 53 0 0 0 0 0 % P
% Gln: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 6 0 0 0 65 0 0 0 0 12 6 % R
% Ser: 0 65 0 24 0 6 0 77 12 0 0 0 12 30 12 % S
% Thr: 6 0 0 42 0 12 12 0 12 6 6 0 0 0 0 % T
% Val: 0 0 12 0 24 0 0 0 0 0 6 0 6 18 12 % V
% Trp: 6 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 12 6 0 0 0 0 0 0 12 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _