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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLDN7
All Species:
21.52
Human Site:
Y201
Identified Species:
52.59
UniProt:
O95471
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95471
NP_001298.3
211
22390
Y201
G
Y
R
A
P
R
S
Y
P
K
S
N
S
S
K
Chimpanzee
Pan troglodytes
XP_511974
211
22381
Y201
G
Y
R
A
P
R
S
Y
P
K
S
N
S
S
K
Rhesus Macaque
Macaca mulatta
XP_001107265
211
22494
Y201
G
Y
H
A
P
R
S
Y
P
K
S
N
S
S
K
Dog
Lupus familis
XP_546584
217
22875
Y207
G
Y
R
A
P
R
S
Y
P
K
P
N
S
A
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z261
211
22341
Y201
A
Y
R
A
P
R
S
Y
P
K
S
N
S
S
K
Rat
Rattus norvegicus
Q9Z1L1
211
22413
Y201
A
Y
R
A
P
R
S
Y
P
K
S
N
S
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511907
211
22724
K201
P
T
P
R
P
Y
P
K
P
A
P
S
S
G
K
Chicken
Gallus gallus
NP_001013629
211
22608
K201
P
P
S
R
G
Y
P
K
N
A
P
S
T
G
K
Frog
Xenopus laevis
NP_001079709
213
22712
A201
K
G
Y
P
K
S
G
A
K
S
K
V
P
S
S
Zebra Danio
Brachydanio rerio
Q9YH92
215
22846
P201
N
Y
P
K
S
S
R
P
V
K
S
S
R
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.6
91.2
N.A.
92.4
93.3
N.A.
59.2
58.2
64.3
59.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.5
94.4
N.A.
95.7
96.2
N.A.
81
77.7
80.2
73.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
86.6
N.A.
93.3
93.3
N.A.
26.6
6.6
6.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
33.3
20
6.6
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
0
60
0
0
0
10
0
20
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
40
10
0
0
10
0
10
0
0
0
0
0
0
20
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
10
10
0
0
20
10
70
10
0
0
0
80
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
10
0
0
60
0
0
0
% N
% Pro:
20
10
20
10
70
0
20
10
70
0
30
0
10
10
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
50
20
0
60
10
0
0
0
0
0
10
0
0
% R
% Ser:
0
0
10
0
10
20
60
0
0
10
60
30
70
60
10
% S
% Thr:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% T
% Val:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
70
10
0
0
20
0
60
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _