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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX6
All Species:
27.88
Human Site:
S227
Identified Species:
51.11
UniProt:
O95475
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95475
NP_031400.2
246
27687
S227
T
S
P
A
A
S
L
S
S
K
A
A
T
S
A
Chimpanzee
Pan troglodytes
XP_522870
514
56142
S495
T
S
P
A
A
S
L
S
S
K
A
A
T
S
A
Rhesus Macaque
Macaca mulatta
XP_001094228
396
43626
S377
A
S
P
A
A
S
L
S
S
K
A
A
T
S
A
Dog
Lupus familis
XP_547840
343
38064
S324
A
S
P
A
A
S
L
S
S
K
A
A
T
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ28
246
27723
S227
S
S
P
A
A
S
L
S
S
K
A
A
T
S
A
Rat
Rattus norvegicus
NP_076480
337
35742
R318
S
V
S
S
L
T
E
R
A
D
T
G
T
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O93307
246
27619
S227
S
S
P
A
V
S
L
S
S
K
A
A
T
S
A
Frog
Xenopus laevis
P79937
390
42868
D361
P
I
G
G
F
V
M
D
G
Q
Q
H
M
G
I
Zebra Danio
Brachydanio rerio
NP_957399
245
27632
S226
S
S
P
E
V
S
L
S
S
K
A
A
T
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95RW8
487
52401
Q265
S
P
V
P
S
S
L
Q
L
Q
H
S
P
G
S
Honey Bee
Apis mellifera
XP_623764
475
51466
M407
E
A
H
S
P
P
L
M
A
T
N
L
S
V
T
Nematode Worm
Caenorhab. elegans
Q23175
439
49618
S388
P
S
Q
C
S
P
C
S
N
E
S
L
S
P
K
Sea Urchin
Strong. purpuratus
XP_781696
324
36468
L279
N
S
A
H
S
P
S
L
T
E
G
A
T
C
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.8
61.3
70.5
N.A.
97.9
59
N.A.
N.A.
93.5
20.2
90.6
N.A.
39.2
41.2
35
57.4
Protein Similarity:
100
47.8
61.3
70.8
N.A.
99.1
65.5
N.A.
N.A.
95.9
33.3
94.3
N.A.
43.7
45.4
42.1
63.5
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
13.3
N.A.
N.A.
86.6
0
80
N.A.
13.3
6.6
13.3
20
P-Site Similarity:
100
100
93.3
93.3
N.A.
100
40
N.A.
N.A.
93.3
13.3
86.6
N.A.
46.6
33.3
46.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
8
47
39
0
0
0
16
0
54
62
0
0
54
% A
% Cys:
0
0
0
8
0
0
8
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% D
% Glu:
8
0
0
8
0
0
8
0
0
16
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
8
0
0
0
0
8
0
8
8
0
16
0
% G
% His:
0
0
8
8
0
0
0
0
0
0
8
8
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
16
% I
% Lys:
0
0
0
0
0
0
0
0
0
54
0
0
0
0
8
% K
% Leu:
0
0
0
0
8
0
70
8
8
0
0
16
0
0
8
% L
% Met:
0
0
0
0
0
0
8
8
0
0
0
0
8
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% N
% Pro:
16
8
54
8
8
24
0
0
0
0
0
0
8
8
0
% P
% Gln:
0
0
8
0
0
0
0
8
0
16
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
39
70
8
16
24
62
8
62
54
0
8
8
16
62
8
% S
% Thr:
16
0
0
0
0
8
0
0
8
8
8
0
70
0
8
% T
% Val:
0
8
8
0
16
8
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _