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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX6
All Species:
46.36
Human Site:
Y71
Identified Species:
85
UniProt:
O95475
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95475
NP_031400.2
246
27687
Y71
G
G
N
Y
R
E
L
Y
H
I
L
E
N
H
K
Chimpanzee
Pan troglodytes
XP_522870
514
56142
Y339
G
G
N
Y
R
E
L
Y
H
I
L
E
N
H
K
Rhesus Macaque
Macaca mulatta
XP_001094228
396
43626
Y221
G
G
N
Y
R
E
L
Y
H
I
L
E
N
H
K
Dog
Lupus familis
XP_547840
343
38064
Y168
G
G
N
Y
R
E
L
Y
H
I
L
E
N
H
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ28
246
27723
Y71
G
G
N
Y
R
E
L
Y
H
I
L
E
N
H
K
Rat
Rattus norvegicus
NP_076480
337
35742
Y154
T
G
N
F
R
D
L
Y
H
I
L
E
N
H
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
O93307
246
27619
Y71
T
G
N
Y
R
E
L
Y
H
I
L
E
N
H
K
Frog
Xenopus laevis
P79937
390
42868
I146
P
E
L
D
N
L
M
I
Q
A
I
Q
V
L
R
Zebra Danio
Brachydanio rerio
NP_957399
245
27632
Y71
A
G
N
F
R
E
L
Y
H
I
L
E
N
H
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95RW8
487
52401
Y99
V
G
N
F
R
E
L
Y
A
I
I
E
N
H
K
Honey Bee
Apis mellifera
XP_623764
475
51466
Y96
S
G
H
Y
R
E
L
Y
A
I
L
E
R
H
K
Nematode Worm
Caenorhab. elegans
Q23175
439
49618
Y128
A
S
H
F
R
E
L
Y
A
I
L
E
N
N
K
Sea Urchin
Strong. purpuratus
XP_781696
324
36468
Y136
Q
G
N
Y
R
E
L
Y
H
I
L
E
N
H
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.8
61.3
70.5
N.A.
97.9
59
N.A.
N.A.
93.5
20.2
90.6
N.A.
39.2
41.2
35
57.4
Protein Similarity:
100
47.8
61.3
70.8
N.A.
99.1
65.5
N.A.
N.A.
95.9
33.3
94.3
N.A.
43.7
45.4
42.1
63.5
P-Site Identity:
100
100
100
100
N.A.
100
80
N.A.
N.A.
93.3
0
86.6
N.A.
73.3
73.3
60
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
93.3
26.6
93.3
N.A.
86.6
80
80
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
0
0
0
0
0
24
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
85
0
0
0
0
0
93
0
0
0
% E
% Phe:
0
0
0
31
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
39
85
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
16
0
0
0
0
0
70
0
0
0
0
85
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
93
16
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
85
% K
% Leu:
0
0
8
0
0
8
93
0
0
0
85
0
0
8
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
77
0
8
0
0
0
0
0
0
0
85
8
0
% N
% Pro:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
8
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
93
0
0
0
0
0
0
0
8
0
16
% R
% Ser:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
62
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _