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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA1 All Species: 16.97
Human Site: T483 Identified Species: 33.94
UniProt: O95477 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.36
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95477 NP_005493.2 2261 254286 T483 S S N G S V Y T W R E A F N E
Chimpanzee Pan troglodytes XP_001138040 2261 254230 T483 S S N G S V Y T W R E A F N E
Rhesus Macaque Macaca mulatta XP_001106713 1081 120445
Dog Lupus familis XP_538773 2261 253895 T483 S A N G S V Y T W R E A F N E
Cat Felis silvestris
Mouse Mus musculus P41233 2261 253955 T483 S P N G S V Y T W R E A F N E
Rat Rattus norvegicus Q7TNJ2 2170 237702 D469 V K I R M D I D D V T R T N K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 N488 S S N G S M Y N W R D A F N E
Chicken Gallus gallus NP_989476 2260 254054 T484 A D N G M V Y T W V D A F N E
Frog Xenopus laevis NP_001089022 2363 267334 D498 P E G Q V N Y D W R N A F N I
Zebra Danio Brachydanio rerio XP_683123 2330 265308 D498 F M N M T S F D W S D V F R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 D68 Q V K G T V E D V F L E S N F
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 L246 S S A L R F E L P W T L F S P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 47 94.9 N.A. 95 50.8 N.A. 89.1 85.4 49.8 51.1 N.A. N.A. N.A. 24.9 N.A.
Protein Similarity: 100 99.7 47.5 97.6 N.A. 97.3 67.4 N.A. 94.6 92.6 66.8 67.8 N.A. N.A. N.A. 43 N.A.
P-Site Identity: 100 100 0 93.3 N.A. 93.3 6.6 N.A. 80 66.6 40 20 N.A. N.A. N.A. 20 N.A.
P-Site Similarity: 100 100 0 100 N.A. 93.3 13.3 N.A. 93.3 80 40 40 N.A. N.A. N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 43.8 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 9 0 0 0 0 0 0 0 0 59 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 0 0 0 9 0 34 9 0 25 0 0 0 0 % D
% Glu: 0 9 0 0 0 0 17 0 0 0 34 9 0 0 50 % E
% Phe: 9 0 0 0 0 9 9 0 0 9 0 0 75 0 9 % F
% Gly: 0 0 9 59 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 9 0 0 0 9 0 0 0 0 0 0 0 9 % I
% Lys: 0 9 9 0 0 0 0 0 0 0 0 0 0 0 9 % K
% Leu: 0 0 0 9 0 0 0 9 0 0 9 9 0 0 9 % L
% Met: 0 9 0 9 17 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 59 0 0 9 0 9 0 0 9 0 0 75 0 % N
% Pro: 9 9 0 0 0 0 0 0 9 0 0 0 0 0 9 % P
% Gln: 9 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 9 9 0 0 0 0 50 0 9 0 9 0 % R
% Ser: 50 34 0 0 42 9 0 0 0 9 0 0 9 9 0 % S
% Thr: 0 0 0 0 17 0 0 42 0 0 17 0 9 0 0 % T
% Val: 9 9 0 0 9 50 0 0 9 17 0 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 67 9 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 59 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _