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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: H6PD All Species: 19.39
Human Site: S721 Identified Species: 35.56
UniProt: O95479 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95479 NP_004276.2 791 88893 S721 Q L V V L T T S P S Q P H R R
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001099298 791 88822 S721 Q L V V L T T S P S Q P H R R
Dog Lupus familis XP_546762 789 89091 S719 Q P V V L T R S P Y K P H Q R
Cat Felis silvestris
Mouse Mus musculus Q8CFX1 789 88892 S719 Q L V V L T E S P F R P H Q R
Rat Rattus norvegicus P05370 515 59357 R454 G S Q M H F V R S D E L R E A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513087 312 34898 V251 D A A A A S M V A V P E S I W
Chicken Gallus gallus XP_425746 782 88274 S712 Q A V V L T E S P V K P H Q R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_697820 781 88168 S711 R L V T L T E S P I K P H Q R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P12646 524 60412 L463 H F V R S D E L R E A W R I F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q27464 522 60197 V461 M G S Q I N F V R T D E L E Y
Sea Urchin Strong. purpuratus XP_795087 853 96259 G781 N F V L F S D G A V Q S S S P
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001150684 507 57610 R446 G D Q Q H F V R R D E L Q A A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11412 505 57503 W444 D D E L D I S W G I F T P L L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.4 84.8 N.A. 83.4 23.1 N.A. 30.5 69.2 N.A. 53 N.A. 22.1 N.A. 22.8 39.9
Protein Similarity: 100 N.A. 98.4 91.6 N.A. 90.3 38.4 N.A. 35.4 82.3 N.A. 71.8 N.A. 37.9 N.A. 39.3 55.9
P-Site Identity: 100 N.A. 100 66.6 N.A. 73.3 0 N.A. 0 66.6 N.A. 60 N.A. 6.6 N.A. 0 13.3
P-Site Similarity: 100 N.A. 100 80 N.A. 86.6 13.3 N.A. 6.6 80 N.A. 80 N.A. 6.6 N.A. 13.3 26.6
Percent
Protein Identity: N.A. 25.2 N.A. N.A. 22.6 N.A.
Protein Similarity: N.A. 39.7 N.A. N.A. 36.7 N.A.
P-Site Identity: N.A. 0 N.A. N.A. 0 N.A.
P-Site Similarity: N.A. 6.6 N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 16 8 8 8 0 0 0 16 0 8 0 0 8 16 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 16 0 0 8 8 8 0 0 16 8 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 31 0 0 8 16 16 0 16 0 % E
% Phe: 0 16 0 0 8 16 8 0 0 8 8 0 0 0 8 % F
% Gly: 16 8 0 0 0 0 0 8 8 0 0 0 0 0 0 % G
% His: 8 0 0 0 16 0 0 0 0 0 0 0 47 0 0 % H
% Ile: 0 0 0 0 8 8 0 0 0 16 0 0 0 16 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 24 0 0 0 0 % K
% Leu: 0 31 0 16 47 0 0 8 0 0 0 16 8 8 8 % L
% Met: 8 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 8 0 0 0 0 0 0 47 0 8 47 8 0 8 % P
% Gln: 39 0 16 16 0 0 0 0 0 0 24 0 8 31 0 % Q
% Arg: 8 0 0 8 0 0 8 16 24 0 8 0 16 16 47 % R
% Ser: 0 8 8 0 8 16 8 47 8 16 0 8 16 8 0 % S
% Thr: 0 0 0 8 0 47 16 0 0 8 0 8 0 0 0 % T
% Val: 0 0 62 39 0 0 16 16 0 24 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _