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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTRAP All Species: 35.76
Human Site: Y168 Identified Species: 60.51
UniProt: O95551 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95551 NP_057698.2 362 40930 Y168 L K K R S S N Y E I I T G H E
Chimpanzee Pan troglodytes XP_518271 384 43414 Y198 L K K R S S N Y E I I T G H E
Rhesus Macaque Macaca mulatta XP_001105245 467 52209 Y281 L K K R A S D Y E I I T G H E
Dog Lupus familis XP_535904 353 40065 Y159 L K K R A H S Y E I I T G H E
Cat Felis silvestris
Mouse Mus musculus Q9JJX7 370 41015 Y178 L K K R A A S Y T I I T G N E
Rat Rattus norvegicus NP_001030119 366 40775 Y174 L R K R A R T Y N I I T G N E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520864 119 13911
Chicken Gallus gallus XP_419093 369 40984 Y175 L Q R R A G G Y T I I P G N V
Frog Xenopus laevis NP_001092156 371 41428 Y177 L K K R A V S Y K I I T G N E
Zebra Danio Brachydanio rerio Q5XJA0 369 41485 Y177 L K K R A V S Y L F F E G S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_493461 362 40875 Y174 I D K L Q S L Y K I Y Y S N K
Sea Urchin Strong. purpuratus XP_001201354 242 26981 T83 A R L S S K Y T I H A A N S I
Poplar Tree Populus trichocarpa XP_002332611 422 47031 Q211 S S W W K A Y Q C S V S S E I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_563894 441 48977 Y178 T C L K I L S Y N V W F R E D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.6 73 81.7 N.A. 66.4 65.5 N.A. 23.2 62.8 59.8 46.6 N.A. N.A. N.A. 26.2 27.6
Protein Similarity: 100 91.1 74.5 89.2 N.A. 78.3 78.4 N.A. 28.7 76.4 75.7 62.3 N.A. N.A. N.A. 49.4 39.5
P-Site Identity: 100 100 86.6 80 N.A. 66.6 60 N.A. 0 40 66.6 40 N.A. N.A. N.A. 26.6 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 80 N.A. 0 66.6 93.3 60 N.A. N.A. N.A. 53.3 13.3
Percent
Protein Identity: 24.1 N.A. N.A. 24.4 N.A. N.A.
Protein Similarity: 41.2 N.A. N.A. 41.9 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 50 15 0 0 0 0 8 8 0 0 0 % A
% Cys: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 15 % D
% Glu: 0 0 0 0 0 0 0 0 29 0 0 8 0 15 50 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 8 8 0 0 0 % F
% Gly: 0 0 0 0 0 8 8 0 0 0 0 0 65 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 8 0 0 0 29 0 % H
% Ile: 8 0 0 0 8 0 0 0 8 65 58 0 0 0 15 % I
% Lys: 0 50 65 8 8 8 0 0 15 0 0 0 0 0 8 % K
% Leu: 65 0 15 8 0 8 8 0 8 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 15 0 15 0 0 0 8 36 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % P
% Gln: 0 8 0 0 8 0 0 8 0 0 0 0 0 0 0 % Q
% Arg: 0 15 8 65 0 8 0 0 0 0 0 0 8 0 0 % R
% Ser: 8 8 0 8 22 29 36 0 0 8 0 8 15 15 0 % S
% Thr: 8 0 0 0 0 0 8 8 15 0 0 50 0 0 0 % T
% Val: 0 0 0 0 0 15 0 0 0 8 8 0 0 0 8 % V
% Trp: 0 0 8 8 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 15 79 0 0 8 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _