Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR1A All Species: 22.42
Human Site: S1093 Identified Species: 41.11
UniProt: O95602 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95602 NP_056240.2 1720 194811 S1093 R G A F L S Y S Q K I Q E A V
Chimpanzee Pan troglodytes XP_001135380 1723 195055 S1093 R G A F L S Y S Q K I Q E A V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532976 1699 192037 S1075 K G A F L N Y S Q K I Q A A V
Cat Felis silvestris
Mouse Mus musculus O35134 1717 194092 S1100 K G A F L S F S Q K I Q A A V
Rat Rattus norvegicus O54889 1716 194174 S1100 K G A F L S F S Q K I Q A A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZL98 1390 155685 G812 S G S R V P D G F E N R S L P
Frog Xenopus laevis NP_001082182 1730 195193 S1098 I S P F L L Y S Q K Q L P A V
Zebra Danio Brachydanio rerio XP_001922839 1693 190636 S1086 D G A F L L F S Q K K M S K L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91875 1642 185391 A1060 S W E K K K P A K L R A A F T
Honey Bee Apis mellifera XP_001121092 1665 190473 I1043 N T L Q K K R I S P F T R F S
Nematode Worm Caenorhab. elegans NP_001022450 1737 195064 K1125 K S G K S G T K K S Y F S A F
Sea Urchin Strong. purpuratus XP_794863 1742 194988 H1094 S P F L E F C H K E Y P S I L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P10964 1664 186413 K1079 N Y Y A L L K K Y N P S A L I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 N.A. 90 N.A. 86.8 87.9 N.A. N.A. 27 68.1 67.9 N.A. 43.7 43.6 39.3 46.8
Protein Similarity: 100 99.1 N.A. 94.4 N.A. 93.3 93.8 N.A. N.A. 43.9 81.7 81.3 N.A. 61.4 61.5 57.4 64.4
P-Site Identity: 100 100 N.A. 80 N.A. 80 80 N.A. N.A. 6.6 53.3 46.6 N.A. 0 0 6.6 0
P-Site Similarity: 100 100 N.A. 93.3 N.A. 93.3 93.3 N.A. N.A. 33.3 53.3 60 N.A. 13.3 0 20 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 38.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 56.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 47 8 0 0 0 8 0 0 0 8 39 54 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 0 8 0 0 0 0 16 0 0 16 0 0 % E
% Phe: 0 0 8 54 0 8 24 0 8 0 8 8 0 16 8 % F
% Gly: 0 54 8 0 0 8 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 0 8 0 0 39 0 0 8 8 % I
% Lys: 31 0 0 16 16 16 8 16 24 54 8 0 0 8 0 % K
% Leu: 0 0 8 8 62 24 0 0 0 8 0 8 0 16 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 16 0 0 0 0 8 0 0 0 8 8 0 0 0 0 % N
% Pro: 0 8 8 0 0 8 8 0 0 8 8 8 8 0 8 % P
% Gln: 0 0 0 8 0 0 0 0 54 0 8 39 0 0 0 % Q
% Arg: 16 0 0 8 0 0 8 0 0 0 8 8 8 0 0 % R
% Ser: 24 16 8 0 8 31 0 54 8 8 0 8 31 0 8 % S
% Thr: 0 8 0 0 0 0 8 0 0 0 0 8 0 0 8 % T
% Val: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 47 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 8 0 0 0 31 0 8 0 16 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _