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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR1A All Species: 22.42
Human Site: S1131 Identified Species: 41.11
UniProt: O95602 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95602 NP_056240.2 1720 194811 S1131 W Y E L D E E S R R K Y Q K K
Chimpanzee Pan troglodytes XP_001135380 1723 195055 S1131 W Y E L D E E S R R K Y Q K K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532976 1699 192037 S1113 W G E L D E Q S R R K Y Q K K
Cat Felis silvestris
Mouse Mus musculus O35134 1717 194092 S1138 W Y D L D E E S R W K Y Q K R
Rat Rattus norvegicus O54889 1716 194174 S1138 W H E L D E Q S R R K Y Q K R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZL98 1390 155685 H850 T P T E F F F H T M A G R E G
Frog Xenopus laevis NP_001082182 1730 195193 T1136 W Y S V N E K T L S R Y R R R
Zebra Danio Brachydanio rerio XP_001922839 1693 190636 G1124 W R A L D E S G R M R Y S K K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91875 1642 185391 L1098 R R R F D E G L L K L W K K A
Honey Bee Apis mellifera XP_001121092 1665 190473 W1081 A V S Y M R K W I R T T E E D
Nematode Worm Caenorhab. elegans NP_001022450 1737 195064 A1163 L E E R E Q Y A R G I P K K C
Sea Urchin Strong. purpuratus XP_794863 1742 194988 R1132 R W R E V T D R H R Y E K K T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P10964 1664 186413 S1117 K E P H Y K Q S V K Y D P V L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 N.A. 90 N.A. 86.8 87.9 N.A. N.A. 27 68.1 67.9 N.A. 43.7 43.6 39.3 46.8
Protein Similarity: 100 99.1 N.A. 94.4 N.A. 93.3 93.8 N.A. N.A. 43.9 81.7 81.3 N.A. 61.4 61.5 57.4 64.4
P-Site Identity: 100 100 N.A. 86.6 N.A. 80 80 N.A. N.A. 0 26.6 53.3 N.A. 20 6.6 20 13.3
P-Site Similarity: 100 100 N.A. 93.3 N.A. 93.3 100 N.A. N.A. 13.3 80 60 N.A. 40 26.6 46.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 38.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 56.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 0 0 0 8 0 0 8 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % C
% Asp: 0 0 8 0 54 0 8 0 0 0 0 8 0 0 8 % D
% Glu: 0 16 39 16 8 62 24 0 0 0 0 8 8 16 0 % E
% Phe: 0 0 0 8 8 8 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 0 0 8 8 0 8 0 8 0 0 8 % G
% His: 0 8 0 8 0 0 0 8 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % I
% Lys: 8 0 0 0 0 8 16 0 0 16 39 0 24 70 31 % K
% Leu: 8 0 0 47 0 0 0 8 16 0 8 0 0 0 8 % L
% Met: 0 0 0 0 8 0 0 0 0 16 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 8 8 0 0 0 0 0 0 0 0 8 8 0 0 % P
% Gln: 0 0 0 0 0 8 24 0 0 0 0 0 39 0 0 % Q
% Arg: 16 16 16 8 0 8 0 8 54 47 16 0 16 8 24 % R
% Ser: 0 0 16 0 0 0 8 47 0 8 0 0 8 0 0 % S
% Thr: 8 0 8 0 0 8 0 8 8 0 8 8 0 0 8 % T
% Val: 0 8 0 8 8 0 0 0 8 0 0 0 0 8 0 % V
% Trp: 54 8 0 0 0 0 0 8 0 8 0 8 0 0 0 % W
% Tyr: 0 31 0 8 8 0 8 0 0 0 16 54 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _