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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR1A All Species: 24.24
Human Site: S1280 Identified Species: 44.44
UniProt: O95602 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O95602 NP_056240.2 1720 194811 S1280 K A L K R V K S L K K Q L T R
Chimpanzee Pan troglodytes XP_001135380 1723 195055 S1280 K A L K R V K S L K K Q L T R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532976 1699 192037 S1262 K A L K R V K S L K K Q L T R
Cat Felis silvestris
Mouse Mus musculus O35134 1717 194092 S1287 K A L K K V K S L K K R L T R
Rat Rattus norvegicus O54889 1716 194174 S1287 K A L R R V K S L K K Q L T R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZL98 1390 155685 V999 N G T T E P R V L Y Q L D R I
Frog Xenopus laevis NP_001082182 1730 195193 Q1285 K A V K R A K Q L K K R L T R
Zebra Danio Brachydanio rerio XP_001922839 1693 190636 T1273 K A L K Q V K T L R K K I T R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91875 1642 185391 R1247 Q H Q A E K L R I N L N S V T
Honey Bee Apis mellifera XP_001121092 1665 190473 N1230 K N V I K R S N K L K L K L T
Nematode Worm Caenorhab. elegans NP_001022450 1737 195064 Y1312 K R E L D R V Y L K Q L L K N
Sea Urchin Strong. purpuratus XP_794863 1742 194988 R1281 I S A K K I G R I C R Q L S R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P10964 1664 186413 V1266 S K V L L S E V I D K V I V T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 N.A. 90 N.A. 86.8 87.9 N.A. N.A. 27 68.1 67.9 N.A. 43.7 43.6 39.3 46.8
Protein Similarity: 100 99.1 N.A. 94.4 N.A. 93.3 93.8 N.A. N.A. 43.9 81.7 81.3 N.A. 61.4 61.5 57.4 64.4
P-Site Identity: 100 100 N.A. 100 N.A. 86.6 93.3 N.A. N.A. 6.6 73.3 66.6 N.A. 0 13.3 26.6 26.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 20 86.6 100 N.A. 13.3 33.3 33.3 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 38.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 56.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 54 8 8 0 8 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 0 8 0 0 8 0 0 % D
% Glu: 0 0 8 0 16 0 8 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 8 0 8 0 0 24 0 0 0 16 0 8 % I
% Lys: 70 8 0 54 24 8 54 0 8 54 70 8 8 8 0 % K
% Leu: 0 0 47 16 8 0 8 0 70 8 8 24 62 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 8 0 0 0 0 0 8 0 8 0 8 0 0 8 % N
% Pro: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 8 0 8 0 0 8 0 0 16 39 0 0 0 % Q
% Arg: 0 8 0 8 39 16 8 16 0 8 8 16 0 8 62 % R
% Ser: 8 8 0 0 0 8 8 39 0 0 0 0 8 8 0 % S
% Thr: 0 0 8 8 0 0 0 8 0 0 0 0 0 54 24 % T
% Val: 0 0 24 0 0 47 8 16 0 0 0 8 0 16 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _