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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLR1A
All Species:
19.09
Human Site:
Y1170
Identified Species:
35
UniProt:
O95602
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95602
NP_056240.2
1720
194811
Y1170
F
E
T
K
V
D
D
Y
S
Q
E
W
A
A
Q
Chimpanzee
Pan troglodytes
XP_001135380
1723
195055
Y1170
F
E
T
K
V
D
D
Y
S
Q
E
W
A
A
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532976
1699
192037
Y1152
F
E
K
K
V
D
D
Y
S
L
E
W
A
A
Q
Cat
Felis silvestris
Mouse
Mus musculus
O35134
1717
194092
F1177
F
E
K
K
I
D
D
F
S
Q
E
W
A
A
Q
Rat
Rattus norvegicus
O54889
1716
194174
Y1177
F
E
K
K
I
D
D
Y
S
Q
E
W
A
A
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZL98
1390
155685
T889
L
C
S
Q
Y
D
L
T
V
R
S
S
T
G
D
Frog
Xenopus laevis
NP_001082182
1730
195193
Y1175
F
Q
S
K
M
A
Q
Y
G
C
A
W
E
Q
Q
Zebra Danio
Brachydanio rerio
XP_001922839
1693
190636
Y1163
F
D
S
I
V
E
S
Y
L
N
Q
F
N
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91875
1642
185391
V1137
Q
D
L
Y
Y
G
S
V
S
E
R
T
R
K
L
Honey Bee
Apis mellifera
XP_001121092
1665
190473
L1120
F
G
V
L
S
E
R
L
E
N
L
I
D
E
Y
Nematode Worm
Caenorhab. elegans
NP_001022450
1737
195064
R1202
I
E
G
F
C
T
R
R
V
K
K
V
D
D
E
Sea Urchin
Strong. purpuratus
XP_794863
1742
194988
L1171
E
S
L
L
Q
D
Y
L
D
S
R
L
P
T
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P10964
1664
186413
K1156
D
K
N
S
K
L
F
K
S
S
D
G
V
N
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
N.A.
90
N.A.
86.8
87.9
N.A.
N.A.
27
68.1
67.9
N.A.
43.7
43.6
39.3
46.8
Protein Similarity:
100
99.1
N.A.
94.4
N.A.
93.3
93.8
N.A.
N.A.
43.9
81.7
81.3
N.A.
61.4
61.5
57.4
64.4
P-Site Identity:
100
100
N.A.
86.6
N.A.
80
86.6
N.A.
N.A.
6.6
33.3
20
N.A.
6.6
6.6
6.6
6.6
P-Site Similarity:
100
100
N.A.
86.6
N.A.
93.3
93.3
N.A.
N.A.
26.6
53.3
60
N.A.
20
13.3
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
38.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
56.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
0
0
8
0
39
39
0
% A
% Cys:
0
8
0
0
8
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
8
16
0
0
0
54
39
0
8
0
8
0
16
8
8
% D
% Glu:
8
47
0
0
0
16
0
0
8
8
39
0
8
8
16
% E
% Phe:
62
0
0
8
0
0
8
8
0
0
0
8
0
0
0
% F
% Gly:
0
8
8
0
0
8
0
0
8
0
0
8
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
8
16
0
0
0
0
0
0
8
0
8
0
% I
% Lys:
0
8
24
47
8
0
0
8
0
8
8
0
0
8
8
% K
% Leu:
8
0
16
16
0
8
8
16
8
8
8
8
0
0
8
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
16
0
0
8
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
8
8
0
8
8
0
8
0
0
31
8
0
0
8
47
% Q
% Arg:
0
0
0
0
0
0
16
8
0
8
16
0
8
0
0
% R
% Ser:
0
8
24
8
8
0
16
0
54
16
8
8
0
0
8
% S
% Thr:
0
0
16
0
0
8
0
8
0
0
0
8
8
8
0
% T
% Val:
0
0
8
0
31
0
0
8
16
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
47
0
0
0
% W
% Tyr:
0
0
0
8
16
0
8
47
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _